Vitamin D and multiple sclerosis

被引：398

作者：

Ascherio, Alberto ^{[1
,2
,3
,4
]}

Munger, Kassandra L. ^{[1
]}

Simon, K. Claire ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Med, Channing Lab, Boston, MA USA

[4] Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

LANCET NEUROLOGY | 2010年 / 9卷 / 06期

关键词：

D-RECEPTOR GENE; D-BINDING PROTEIN; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; 25-HYDROXYVITAMIN D CONCENTRATIONS; RESPIRATORY-TRACT INFECTION; ENVIRONMENTAL SUN EXPOSURE; RESONANCE-IMAGING LESIONS; UNITED-STATES VETERANS; D-ENDOCRINE SYSTEM;

D O I：

10.1016/S1474-4422(10)70086-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The hypothesis that adequate vitamin D nutrition can contribute to the prevention of multiple sclerosis (MS) was originally proposed to explain the geographical distribution of MS, but only recently has the relation between various measures of vitamin D (eg, sun exposure, dietary sources, and serum concentrations of 25-hydroxyvitamin D) and risk of developing MS been rigorously investigated. Overall, the results of these studies support a protective effect of vitamin D, but there are uncertainties and many unanswered questions, including how vitamin D exerts a protective effect, how genetic variations modify the effect, and whether vitamin D can influence the course of MS progression.

引用

页码：599 / 612

页数：14

共 199 条

[41] Diagnostic value of antibodies against a modified citrullinated vimentin in rheumatoid arthritis [J].

Dejaco, Christian ;

Klotz, Werner ;

Larcher, Heike ;

Duftner, Christina ;

Schirmer, Michael ;

Herold, Manfred .

ARTHRITIS RESEARCH & THERAPY, 2006, 8 (04)

[42] Vitamin D: its role and uses in immunology [J].

Deluca, HF ;

Cantorna, MT .

FASEB JOURNAL, 2001, 15 (14) :2579-2585

[43] Past environmental sun exposure and risk of multiple sclerosis: a role for the Cdx-2 Vitamin D receptor variant in this interaction [J].

Dickinson, J. L. ;

Perera, D. I. ;

van der Mei, A. F. ;

Ponsonby, A-L ;

Polanowski, A. M. ;

Thomson, R. J. ;

Taylor, B. V. ;

McKay, J. D. ;

Stankovich, J. ;

Dwyer, T. .

MULTIPLE SCLEROSIS, 2009, 15 (05) :563-570

[44] Melanocortin 1 receptor genotype, past environmental sun exposure, and risk of multiple sclerosis [J].

Dwyer, T. ;

van der Mei, I. ;

Ponsonby, A. -L. ;

Taylor, B. V. ;

Stankovich, J. ;

McKay, J. D. ;

Thomson, R. J. ;

Polanowski, A. M. ;

Dickinson, J. L. .

NEUROLOGY, 2008, 71 (08) :583-589

[45] Genetics of multiple sclerosis [J].

Dyment, DA ;

Ebers, GC ;

Sadovnick, AD .

LANCET NEUROLOGY, 2004, 3 (02) :104-110

[46]

Embry AF, 2000, ANN NEUROL, V48, P271, DOI 10.1002/1531-8249(200008)48:2<271::AID-ANA28>3.0.CO

[47]

2-O

[48] Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans [J].

Engelman, Corinne D. ;

Fingerlin, Tasha E. ;

Langefeld, Carl D. ;

Hicks, Pamela J. ;

Rich, Stephen S. ;

Wagenknecht, Lynne E. ;

Bowden, Donald W. ;

Norris, Jill M. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (09) :3381-3388

[49] Daily duration of vitamin D synthesis in human skin with relation to latitude, total ozone, altitude, ground cover, aerosols and cloud thickness [J].

Engelsen, O ;

Brustad, M ;

Aksnes, L ;

Lund, E .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2005, 81 (06) :1287-1290

[50]

Ferrari Serge L., 2005, Molecular Aspects of Medicine, V26, P145, DOI 10.1016/j.mam.2005.01.002

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