High-throughput analytical techniques for reaction optimization

被引：9

作者：

Congreve, MS

Jamieson, C

机构：

[1] Astex Technol, Cambridge CB4 0WE, England

[2] GlaxoSmithKline R&D, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

DRUG DISCOVERY TODAY | 2002年 / 7卷 / 02期

关键词：

D O I：

10.1016/S1359-6446(02)00009-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review describes recent developments in approaches to high-throughput reaction optimization, as well as the associated analytical techniques. The studies discussed include the use of UV-visible, IR-thermographic and mass spectrometric methods for application in catalyst development, process optimization and materials science. Other methods of potential use in a high-throughput format are also discussed.

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页码：139 / 142

页数：4

相关论文

共 54 条

[1] A combined parallel synthesis and screening of macrocyclic lanthanide complexes for the cleavage of phospho di- and triesters and double-stranded DNA [J].

Berg, T ;

Simeonov, A ;

Janda, KD .

JOURNAL OF COMBINATORIAL CHEMISTRY, 1999, 1 (01) :96-100

[2]

Boussie TR, 1998, ANGEW CHEM INT EDIT, V37, P3272, DOI 10.1002/(SICI)1521-3773(19981217)37:23<3272::AID-ANIE3272>3.0.CO

[3]

2-R

[4]

BRAY AM, 1995, TETRAHEDRON LETT, V36, P5081

[5] A parallel combinatorial approach to locating homochiral Lewis acid catalysts for the asymmetric aza-Diels-Alder reaction of an imino dienophile. [J].

Bromidge, S ;

Wilson, PC ;

Whiting, A .

TETRAHEDRON LETTERS, 1998, 39 (48) :8905-8908

[6] New catalysts and conditions for a C-H insertion reaction identified by high throughput catalyst screening [J].

Burgess, K ;

Lim, HJ ;

Porte, AM ;

Sulikowski, GA .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (02) :220-222

[7] Discovery of chiral catalysts through ligand diversity: Ti-catalyzed enantioselective addition of TMSCN to meso epoxides [J].

Cole, BM ;

Shimizu, KD ;

Krueger, CA ;

Harrity, JPA ;

Snapper, ML ;

Hoveyda, AH .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (15) :1668-1671

[8] Reactive dyes as a method for rapid screening of homogeneous catalysts [J].

Cooper, AC ;

McAlexander, LH ;

Lee, DH ;

Torres, MT ;

Crabtree, RH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (38) :9971-9972

[9] Selection of enantioselective acyl transfer catalysts from a pooled peptide library through a fluorescence-based activity assay: An approach to kinetic resolution of secondary alcohols of broad structural scope [J].

Copeland, GT ;

Miller, SJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (27) :6496-6502

[10] A chemosensor-based approach to catalyst discovery in solution and on solid support [J].

Copeland, GT ;

Miller, SJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (17) :4306-4307

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