Troglitazone suppresses cell growth of KU812 cells independently of PPAR-γ

被引：53

作者：

Abe, A

Kiriyama, Y

Hirano, M

Miura, T

Kamiya, H

Harashima, H

Tokumitsu, Y ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Physiol Chem Lab, Sapporo, Hokkaido 0600812, Japan

[2] Hokkaido Univ, Grad Sch Pharmaceut Sci, Lab Mol Design Pharmaceut, Sapporo, Hokkaido 0600812, Japan

[3] Hokkaido Univ, Coll Med Technol, Sapporo, Hokkaido 0600812, Japan

[4] Hlth Sci Univ Hokkaido, Ishikari 0610293, Japan

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2002年 / 436卷 / 1-2期

关键词：

thiazolidinedione; PPAR (peroxisome proliferator-activated receptor); KU812; cell; cell growth; histamine secretion;

D O I：

10.1016/S0014-2999(01)01577-1

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

We examined the effects of troglitazone, one of thiazolidinedione derivatives on human basophilic leukemia cell line KU812. Troglitazone caused the suppression of cell growth, which was suggested to result from the decrease in cyclin E and the hyperphosphorylated form of retinoblastoma tumor suppressor gene product (pRb). In addition, troglitazone caused a decrease in histamine secretion due to the reduced expression of histidine decarboxylase mRNA. Peroxisome proliferator-activated receptor (PPAR)-gamma mRNA was undetectable by reverse transcription-polymerase chain reaction (RT-PCR) in KU812 cells. These findings suggested that troglitazone suppressed cell growth and histamine synthesis independently of PPARgamma. (C) 2002 Published by Elsevier Science B.V.

引用

页码：7 / 13

页数：7

共 30 条

[1]

Asou H, 1999, INT J ONCOL, V15, P1027

[2]

INHIBITION OF PROTEIN-KINASE-C ACTIVITY AND VASCULAR SMOOTH-MUSCLE CELL-GROWTH BY D-ALPHA-TOCOPHEROL [J].