PDMAEMA based gene delivery materials

被引：317

作者：

Agarwal, Seema ^{[1
]}

Zhang, Yi

Maji, Samarendra

Greiner, Andreas

机构：

[1] Univ Marburg, Dept Chem, D-35032 Marburg, Germany

来源：

MATERIALS TODAY | 2012年 / 15卷 / 09期

关键词：

IN-VITRO; TRANSFECTION EFFICIENCY; BIOPHYSICAL CHARACTERIZATION; CATIONIC POLYMETHACRYLATES; MOLECULAR-WEIGHT; PLASMID DNA; POLYMERS; DESIGN; METHACRYLATE); COPOLYMERS;

D O I：

10.1016/S1369-7021(12)70165-7

中图分类号：

T [工业技术];

学科分类号：

120111 [工业工程];

摘要：

Gene transfection is the transfer of genetic material like DNA into cells. Cationic polymers which form nanocomplexes with DNA, so-called non-viral gene vectors, are a highly promising platform for efficient gene transfection. Despite intensive research efforts and some of the on-going clinical trials on gene transfection, none of the existing cationic polymer systems are generally acceptable for human gene therapy. Since the process of gene transfection is complex and puts different challenges and demands on the delivery system, there is a strong requirement for the design and development of a multifunctional system in a simple way. This review will discuss recent efforts in design, synthesis, and performance of poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) nanocomplexes with DNA.

引用

收藏

页码：388 / 393

页数：6

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