Gene therapy for tissue repair and regeneration

被引：70

作者：

Bonadio, J

Goldstein, SA

Levy, RJ

机构：

[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Surg, Orthopaed Res Labs,Sect Orthopaed Surg, Ann Arbor, MI 48109 USA

[3] Childrens Hosp Philadelphia, Abramson Pediat Res Ctr, Philadelphia, PA 19104 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1998年 / 33卷 / 1-2期

关键词：

fracture repair; cytokine; plasmid gene transfer; granulation tissue; fibroblast; gene activated matrix;

D O I：

10.1016/S0169-409X(98)00020-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review presents a current overview of the discipline of human gene therapy. In addition, a gene therapy method is described in which plasmid genes are transferred from a structural matrix carrier into fresh wound sites so as to enhance tissue repair and regeneration. The potential to develop a gene therapy for bone regeneration is discussed in detail. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：53 / 69

页数：17

共 185 条

[1] EXPRESSION OF HUMAN BONE MORPHOGENETIC PROTEINS-2 OR PROTEINS-4 IN MURINE MESENCHYMAL PROGENITOR C3H10T1/2 CELLS INDUCES DIFFERENTIATION INTO DISTINCT MESENCHYMAL CELL LINEAGES [J].