Diastereoselective synthesis endo- and exo-spirotetronate of the quartromicins.: The first enantioselective Diels-Alder reaction of an acyclic (Z)-1,3-diene

被引：44

作者：

Roush, WR ^{[1
]}

Limberakis, C ^{[1
]}

Kunz, RK ^{[1
]}

Barda, DA ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 09期

关键词：

D O I：

10.1021/ol025772+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diastereoselective syntheses of the endo- and exo-spirotetronates 1 and 2, corresponding to the galacto and agalacto fragments of quartromicins A(3) and D-3, are described. The key step of these syntheses are highly enantio- and diastereoselective Lewis acid catalyzed Diels-Alder reactions of the 1,1,3,4-tetrasubstituted diene 3.

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页码：1543 / 1546

页数：4

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