Emerging possibilities in the development and function of regulatory T cells

被引：116

作者：

Wing, Kajsa

Fehervari, Zoltan

Sakaguchi, Shimon

机构：

[1] Kyoto Univ, Inst Frontier Med Sci, Dept Expt Pathol, Sakyo Ku, Kyoto 6068507, Japan

[2] CREST, Japan Sci & Technol Agcy, Kawaguchi 3320012, Japan

来源：

INTERNATIONAL IMMUNOLOGY | 2006年 / 18卷 / 07期

关键词：

adaptive regulatory T cell; CTLA-4; Foxp3; natural regulatory T cells; tolerance;

D O I：

10.1093/intimm/dxl044

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD25(+)CD4(+) Regulatory T cells (Treg) represent a unique population of lymphocytes capable of powerfully suppressing immune responses. A large body of experimental data have now confirmed the essential role played by these cells in a host of clinically relevant areas such as self-tolerance, transplantation, allergy and tumor/microbial immunity. Despite this mass of knowledge, significant gaps in our understanding of fundamental Treg biology remain, particularly regarding their development and mechanisms of suppression. In this review we attempt to highlight the current controversies and directions in which this exciting field is moving.

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页码：991 / 1000

页数：10

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