Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype

被引：561

作者：

Barnett, Gillian C. ^{[1
,2
]}

West, Catherine M. L. ^{[3
]}

Dunning, Alison M. ^{[2
]}

Elliott, Rebecca M. ^{[3
]}

Coles, Charlotte E. ^{[1
]}

Pharoah, Paul D. P. ^{[2
]}

Burnet, Neil G. ^{[1
]}

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Ctr Oncol, Dept Oncol, Cambridge CB2 0QQ, England

[2] Strangeways Res Lab, Dept Oncol, Cambridge CB1 8RN, England

[3] Univ Manchester, Christie Hosp, Acad Radiat Oncol, Manchester M20 4BX, Lancs, England

来源：

NATURE REVIEWS CANCER | 2009年 / 9卷 / 02期

关键词：

GENOME-WIDE ASSOCIATION; SINGLE NUCLEOTIDE POLYMORPHISMS; LOW-PENETRANCE PREDISPOSITION; MODULATED RADIATION-THERAPY; IN-VITRO RADIOSENSITIVITY; DOUBLE-STRAND BREAKS; CELLULAR RADIOSENSITIVITY; CHROMOSOMAL RADIOSENSITIVITY; SUBCUTANEOUS FIBROSIS; QUANTITATIVE TRAITS;

D O I：

10.1038/nrc2587

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A key challenge in radiotherapy is to maximize radiation doses to cancer cells while minimizing damage to surrounding healthy tissue. As severe toxicity in a minority of patients limits the doses that can be safely given to the majority, there is interest in developing a test to measure an individual's radiosensitivity before treatment. variation in sensitivity to radiation is an inherited genetic trait and recent progress in genotyping raises the possibility of genome-wide studies to characterize genetic profiles that predict patient response to radiotherapy.

引用

页码：134 / 142

页数：10

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