Maternal separation:: hypothalamic-preoptic area and hippocampal Calbindin-D28K and calretinin in male and female infantile rats

被引：20

作者：

Lephart, ED ^{[1
]}

Watson, MA ^{[1
]}

机构：

[1] Brigham Young Univ, Dept Zool, Div Cell Biol, Provo, UT 84602 USA

来源：

NEUROSCIENCE LETTERS | 1999年 / 267卷 / 01期

基金：

美国国家科学基金会;

关键词：

maternal separation; Calbindin-D-28K; calretinin; hypothalamus; hippocampus; rat; western analysis;

D O I：

10.1016/S0304-3940(99)00326-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Calcium-binding proteins (CaPs) potentially play important roles in neurogenesis and neuronal survival. Calbindin-D-28K (CALB) and calretinin (CALRET) in the media! basal hypothalamic (and preoptic area) (MBH) and hippocampus (HIPPO) from control and maternally separated male and female infantile rats were examined by Western analysis. Significantly greater levels of the CaPs in the MBH vs, the HIPPO may suggest enhanced or decreased neuroprotection, respectively, during the stress hyporesponsive period (SHRP). Male infantile rats separated from their mother's from postnatal day 2-10 displayed significant changes in CALB and CALRET for the MBH (decrease) and HIPP (increase) brain sites suggesting possible modified (negative feedback) mechanism(s) in HPA dysfunction observed during postnatal life. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：41 / 44

页数：4

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