Halistanol disulfate B, a novel sulfated sterol from the sponge Pachastrella sp: Inhibitor of endothelin converting enzyme

被引：23

作者：

Patil, AD

Freyer, AJ

Breen, A

Carte, B

Johnson, RK

机构：

[1] Department of Biomolecular Discovery, SmithKline Beecham Pharmaceut., R., Research and Development, King of Prussia

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 06期

关键词：

D O I：

10.1021/np9601770

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

As part of a search for novel inhibitors of endothelin converting enzyme (ECE), the MeOH extract of a South African sponge, Pachastrella sp., was shown to be active. Bioassay-guided fractionation of the extract yielded a novel sterol sulfate, halistanol disulfate B (1). The structure and stereochemistry of 1 was established mainly by interpretation of spectral data. Disulfate (1) was found to be active at a micromolar concentration in the ECE assay.

引用

页码：606 / 608

页数：3

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