Purification of p-nitrobenzyl C-functionalized diethylenetriamine pentaacetic acids for clinical applications using anion-exchange chromatography

被引：14

作者：

Brechbiel, MW

Beitzel, PM

Gansow, OA

机构：

[1] Radioimmune and Inorg. Chem. Section, Radiation Oncology Branch, NIH, Bethesda

来源：

JOURNAL OF CHROMATOGRAPHY A | 1997年 / 771卷 / 1-2期

关键词：

radioligands; preparative chromatography; diethylenetriamine pentaacetic acids; monoclonal antibodies;

D O I：

10.1016/S0021-9673(97)00108-8

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A general process for the purification of large quantities (5-10 g) of p-nitrobenzyl C-functionalized diethylenetriamine pentaacetic acids is reported. The method of choice to achieve purification for clinical applications is anion-exchange chromatography.

引用

页码：63 / 69

页数：7

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