Leishmania infection and virulence

被引:62
作者
Matlashewski, G [1 ]
机构
[1] McGill Univ, Dept Microbiol & Immunol, Montreal, PQ H3A 2B4, Canada
关键词
D O I
10.1007/s004300100076
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Leishmaniasis is among the most important infectious diseases of the developing world. With the advent of effective culture conditions for the various stages of the life cycle, together with state of the art biochemical, genomics, and reverse genetic approaches, it has been possible to identify virulence factors required for the infection process. Several of these virulence factors are discussed within including lipophosphoglygan, A2, cysteine proteinases, and gp63.
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收藏
页码:37 / 42
页数:6
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共 71 条
[1]  
Alexander J, 1998, J IMMUNOL, V161, P6794
[2]   ESTIMATION OF POPULATION AT RISK OF INFECTION AND NUMBER OF CASES OF LEISHMANIASIS [J].
ASHFORD, RW ;
DESJEUX, P ;
DERAADT, P .
PARASITOLOGY TODAY, 1992, 8 (03) :104-105
[3]   Cathepsin B-like cysteine proteinase-deficient mutants of Leishmania mexicana [J].
Bart, G ;
Frame, MJ ;
Carter, R ;
Coombs, GH ;
Mottram, JC .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1997, 88 (1-2) :53-61
[4]  
Belkaid Y, 1998, EUR J IMMUNOL, V28, P1389, DOI 10.1002/(SICI)1521-4141(199804)28:04&lt
[5]  
1389::AID-IMMU1389&gt
[6]  
3.0.CO
[7]  
2-1
[8]   Human leishmaniasis: Clinical, diagnostic, and chemotherapeutic developments in the last 10 years [J].
Berman, JD .
CLINICAL INFECTIOUS DISEASES, 1997, 24 (04) :684-703
[9]   Lipophosphoglycan (LPG) and the identification of virulence genes in the protozoan parasite Leishmania [J].
Beverley, SM ;
Turco, SJ .
TRENDS IN MICROBIOLOGY, 1998, 6 (01) :35-40
[10]   Exploitation of the complement system by Leishmania promastigotes [J].
Brittingham, A ;
Mosser, DM .
PARASITOLOGY TODAY, 1996, 12 (11) :444-447