Surface Functionalization of Iron Oxide Nanoparticles and their Stability in Different Media

被引:17
作者
Arndt, Darius [1 ]
Gesing, Thorsten M.
Baeumer, Marcus [1 ]
机构
[1] Univ Bremen, Inst Appl & Phys Chem, D-28359 Bremen, Germany
来源
CHEMPLUSCHEM | 2012年 / 77卷 / 07期
关键词
Fenton chemistry; iron oxide; nanoparticles; surface chemistry; sustainable chemistry; SUPERPARAMAGNETIC MAGNETITE NANOPARTICLES; DESIGN; CATALYSTS; TOXICITY; POLYOL; SPIONS; FE; CO;
D O I
10.1002/cplu.201200065
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Size-selective synthesis of very small iron oxide nanoparticles (IONP; 48 nm) was achieved by the thermal decomposition of iron acetylacetonate in diethylenglycol by a simple one-pot reaction. The particles were functionalized on the one hand with poly(vinylpyrrolidone) (PVP) directly during the formation of the particles and on the other hand by a simple postsynthetic reaction with citrate, ascorbate, tartrate, dextran 60, gum Arabic, PVP, or poly(ethyleneglycol) (PEG). In view of medical and environmental applications, the stability of the particles was measured with dynamic light scattering in water as well as in physiological media containing buffers (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (IP-HEPES), phosphate buffered saline (PBS)), high salt concentrations (Elendt M7), or proteins (Dulbeccos modified eagle medium (DMEM) with and without 10?% fetal calf serum (FCS)). The effect of the functionalization of the nanoparticles on the production of radical oxygen species (ROS) was investigated during the Fenton reaction, showing that the nature of the functionalization can raise the production of ROS drastically. To extend the range of applications, the one-pot reaction with PVP was expanded by an additional step, allowing tagging of the particles with various fluorescein derivatives. In this way, fluorescent nanoparticles exhibiting emissions in the range of 475553 nm were obtained.
引用
收藏
页码:576 / 583
页数:8
相关论文
共 56 条
[1]   Ultrastable Iron Oxide Nanoparticle Colloidal Suspensions Using Dispersants with Catechol-Derived Anchor Groups [J].
Amstad, Esther ;
Gillich, Torben ;
Bilecka, Idalia ;
Textor, Marcus ;
Reimhult, Erik .
NANO LETTERS, 2009, 9 (12) :4042-4048
[2]   Nanoparticles as recyclable catalysts: The frontier between homogeneous and heterogeneous catalysis [J].
Astruc, D ;
Lu, F ;
Aranzaes, JR .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (48) :7852-7872
[3]  
Astruc D., 2005, Angew. Chem, V117, P8062, DOI DOI 10.1002/ange.200500766
[4]   SYNTHESIS OF VERY FINE MAGHEMITE PARTICLES [J].
BEE, A ;
MASSART, R ;
NEVEU, S .
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 1995, 149 (1-2) :6-9
[5]   The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications [J].
Boyer, Cyrille ;
Whittaker, Michael R. ;
Bulmus, Volga ;
Liu, Jingquan ;
Davis, Thomas P. .
NPG ASIA MATERIALS, 2010, 2 (01) :23-30
[6]   Facile synthesis of superparamagnetic magnetite nanoparticles in liquid polyols [J].
Cai, Wei ;
Wan, Jiaqi .
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2007, 305 (02) :366-370
[7]   Unique Cellular Interaction of Silver Nanoparticles: Size-Dependent Generation of Reactive Oxygen Species [J].
Carlson, C. ;
Hussain, S. M. ;
Schrand, A. M. ;
Braydich-Stolle, L. K. ;
Hess, K. L. ;
Jones, R. L. ;
Schlager, J. J. .
JOURNAL OF PHYSICAL CHEMISTRY B, 2008, 112 (43) :13608-13619
[8]   Recent advances in iron oxide nanocrystal technology for medical imaging [J].
Corot, Claire ;
Robert, Philippe ;
Idee, Jean-Marc ;
Port, Marc .
ADVANCED DRUG DELIVERY REVIEWS, 2006, 58 (14) :1471-1504
[9]   Applications of Nanoparticles in Biology [J].
De, Mrinmoy ;
Ghosh, Partha S. ;
Rotello, Vincent M. .
ADVANCED MATERIALS, 2008, 20 (22) :4225-4241
[10]   Monodisperse magnetic single-crystal ferrite microspheres [J].
Deng, H ;
Li, XL ;
Peng, Q ;
Wang, X ;
Chen, JP ;
Li, YD .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (18) :2782-2785