Recent advances in iron oxide nanocrystal technology for medical imaging

被引：1463

作者：

Corot, Claire ^{[1
]}

Robert, Philippe ^{[1
]}

Idee, Jean-Marc ^{[1
]}

Port, Marc ^{[1
]}

机构：

[1] Guerbet Res, F-95943 Roissy, France

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2006年 / 58卷 / 14期

关键词：

USPIO; iron oxide nanoparticles; MRI macrophage imaging; MR-cell tracking; MR-molecular imaging;

D O I：

10.1016/j.addr.2006.09.013

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Superparamagnetic iron oxide particles (SPIO and USPIO) have a variety of applications in molecular and cellular imaging. Most of the recent research has concerned cellular imaging with imaging of in vivo macrophage activity. According to the iron oxide nanoparticle composition and size which influence their biodistribution, several clinical applications are possible: detection liver metastases, metastatic lymph nodes, inflammatory and/or degenerative diseases. USPIO are investigated as blood pool agents with T1 weighted sequence for angiography, tumour permeability and tumour blood volume or steady-state cerebral blood volume and vessel size index measurements using T2* weighted sequences. Stem cell migration and immune cell trafficking, as well as targeted iron oxide nanoparticles for molecular imaging studies, are at the stage of proof of concept, mainly in annual models. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：1471 / 1504

页数：34

共 234 条

[1]

Affinity chromatography of human anti-dextran antibodies - Isolation of two distinct populations [J].