Chemokines in the Pathogenesis of Lichenoid Tissue Reactions

被引：43

作者：

Meller, Stephan ^{[1
]}

Gilliet, Michel ^{[2
]}

Homey, Bernhard ^{[1
]}

机构：

[1] Univ Dusseldorf, Dept Dermatol, D-40225 Dusseldorf, Germany

[2] Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2009年 / 129卷 / 02期

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; PLASMACYTOID DENDRITIC CELLS; ALPHA-PRODUCING CELLS; REGULATORY T-CELLS; SELF-RECRUITING MECHANISM; SKIN INFLAMMATION; CYTOTOXIC LYMPHOCYTES; CXC CHEMOKINE; IFN-ALPHA; PLANUS;

D O I：

10.1038/jid.2008.251

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

Clinical manifestations of lichenoid tissue reactions are heterogenous and include the cutaneous lupus erythematosus and lichen planus. Lichenoid tissue reactions are characterized by epidermal basal-cell damage and a variable subepithelial inflammatory infiltrate including cytotoxic T(H)1 cells and plasmacytoid dendritic cells. Here, we summarize the current knowledge of the role of chemokines in the pathophysiology of lichenoid tissue reactions and propose mechanisms by which recruitment and local activation of cytotoxic T(H)1 cells and plasmacytoid dendritic cells may result in initiation and amplification of lichen planus and cutaneous lupus erythematosus.

引用

页码：315 / 319

页数：5

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