Cardiogenesis and the Complex Biology of Regenerative Cardiovascular Medicine

被引：182

作者：

Chien, Kenneth R. ^{[1
,2
,3
]}

Domian, Ibrahim J. ^{[1
]}

Parker, Kevin Kit ^{[4
]}

机构：

[1] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA

[2] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

[3] Harvard Stem Cell Inst, Cambridge, MA 02138 USA

[4] Harvard Univ, Sch Engn & Appl Sci, Dis Biophys Grp, Cambridge, MA 02138 USA

来源：

SCIENCE | 2008年 / 322卷 / 5907期

关键词：

D O I：

10.1126/science.1163267

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The heart is a complex organ system composed of a highly diverse set of muscle and nonmuscle cells. Understanding the pathways that drive the formation, migration, and assembly of these cells into the heart muscle tissue, the pacemaker and conduction system, and the coronary vasculature is a central problem in developmental biology. Efforts to unravel the biological complexity of in vivo cardiogenesis have identified a family of closely related multipotent cardiac progenitor cells. These progenitors must respond to non- cell- autonomous signaling cues to expand, differentiate, and ultimately integrate into the three- dimensional heart structures. Coupling tissue- engineering technologies with patient- specific cardiac progenitor biology holds great promise for the development of human cell models of human disease and may lay the foundation for novel approaches in regenerative cardiovascular medicine.

引用

页码：1494 / 1497

页数：4

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