Unchain my heart: the scientific foundations of cardiac repair

被引：503

作者：

Dimmeler, S

Zeiher, AM

Schneider, MD

机构：

[1] Goethe Univ Frankfurt, Dept Internal Med 4, Div Mol Cardiol, D-60590 Frankfurt, Germany

[2] Baylor Coll Med, Ctr Cardiovasc Dev, Dept Med, Houston, TX USA

[3] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX USA

[4] Baylor Coll Med, Dept Physiol & Mol Biophys, Houston, TX USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 03期

关键词：

D O I：

10.1172/JCI200524283

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In humans, the biological limitations to cardiac regenerative growth create both a clinical imperative - to offset cell death in acute ischemic injury and chronic heart failure - and a clinical opportunity; that is, for using cells, genes, and proteins to rescue cardiac muscle cell number or in other ways promote more efficacious cardiac repair. Recent experimental studies and early-phase clinical trials lend credence to the visionary goal of enhancing cardiac repair as an achievable therapeutic target.

引用

页码：572 / 583

页数：12

共 124 条

[1] Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling
Aicher, A
Brenner, W
Zuhayra, M
Badorff, C
Massoudi, S
Assmus, B
Eckey, T
Henze, E
Zeiher, AM
Dimmeler, S
[J]. CIRCULATION, 2003, 107 (16) : 2134 - 2139
[2] Hypoxic preconditioning augments efficacy of human endothelial progenitor cells for therapeutic neovascularization
Akita, T
Murohara, T
Ikeda, H
Sasaki, KI
Shimada, T
Egami, K
Imaizumi, T
[J]. LABORATORY INVESTIGATION, 2003, 83 (01) : 65 - 73
[3] Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
Alvarez-Dolado, M
Pardal, R
Garcia-Vardugo, JM
Fike, JR
Lee, HO
Pfeffer, K
Lois, C
Morrison, SJ
Alvarez-Buylla, A
[J]. NATURE, 2003, 425 (6961) : 968 - 973
[4] Can stem cells cross lineage boundaries?
Anderson, DJ
Gage, FH
Weissman, IL
[J]. NATURE MEDICINE, 2001, 7 (04) : 393 - 395
[5] Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
Asahara, T
Masuda, H
Takahashi, T
Kalka, C
Pastore, C
Silver, M
Kearne, M
Magner, M
Isner, JM
[J]. CIRCULATION RESEARCH, 1999, 85 (03) : 221 - 228
[6] VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells
Asahara, T
Takahashi, T
Masuda, H
Kalka, C
Chen, DH
Iwaguro, H
Inai, Y
Silver, M
Isner, JM
[J]. EMBO JOURNAL, 1999, 18 (14) : 3964 - 3972
[7] Cellular, but not direct, adenoviral delivery of vascular endothelial growth factor results in improved left ventricular function and neovascularization in dilated ischemic cardiomyopathy
Askari, A
Unzek, S
Goldman, CK
Ellis, SG
Thomas, JD
DiCorleto, PE
Topol, EJ
Penn, MS
[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 43 (10) : 1908 - 1914
[8] Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy
Askari, AT
Unzek, S
Popovic, ZB
Goldman, CK
Forudi, F
Kiedrowski, M
Rovner, A
Ellis, SG
Thomas, JD
DiCorleto, PE
Topol, EJ
Penn, MS
[J]. LANCET, 2003, 362 (9385) : 697 - 703
[9] HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes
Assmus, B
Urbich, C
Aicher, A
Hofmann, WK
Haendeler, J
Rössig, L
Spyridopoulos, I
Zeiher, AM
Dimmeler, S
[J]. CIRCULATION RESEARCH, 2003, 92 (09) : 1049 - 1055
[10] Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction -: (TOPCARE-AMI)
Assmus, B
Schächinger, V
Teupe, C
Britten, M
Lehmann, R
Döbert, N
Grünwald, F
Aicher, A
Urbich, C
Martin, H
Hoelzer, D
Dimmeler, S
Zeiher, AM
[J]. CIRCULATION, 2002, 106 (24) : 3009 - 3017

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