An overview of the KIN1/PAR-1/MARK kinase family

被引：90

作者：

Tassan, JP ^{[1
]}

Le Goff, X ^{[1
]}

机构：

[1] Univ Rennes 1, IFR Genom Fonctionnelle & Sante 97, Fac Med, CNRS,UMR6061, F-35043 Rennes, France

来源：

BIOLOGY OF THE CELL | 2004年 / 96卷 / 03期

关键词：

cell polarity; cell cycle; cell signalling; microtubules;

D O I：

10.1016/j.biolcel.2003.10.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Members of the KIN1/PAR-1/MARK kinase family are conserved from yeast to humans and share a similar primary structural organization. Several kinases of this family appear to be at the crossroads of various biological functions including cell polarity, cell cycle control, intracellular signalisation, microtubules stability and protein stability. Here we present an overview of known roles of KIN1/PAR-1/MARK kinases including pEg3 a newly identified member which is regulated during the cell cycle and is a potential regulator of the cell cycle progression. Some common modes of action can be deciphered for this protein kinase family. (C) 2004 Elsevier SAS. All rights reserved.

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页码：193 / 199

页数：7

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