PROTEIN CARBONYLATION: PROTEOMICS, SPECIFICITY AND RELEVANCE TO AGING

被引：70

作者：

Cabiscol, Elisa ^{[1
]}

Tamarit, Jordi ^{[1
]}

Ros, Joaquim ^{[1
]}

机构：

[1] Univ Lleida, IRB Lleida, Dept Ciencies Med Basiques, Lleida 25198, Catalonia, Spain

来源：

MASS SPECTROMETRY REVIEWS | 2014年 / 33卷 / 01期

关键词：

protein carbonylation; aging; proteomics; carbonyl detection; metal-catalyzed oxidation; oxidative stress; specific damage; METAL-CATALYZED OXIDATION; ACID-BINDING PROTEIN; AGE-RELATED-CHANGES; CALORIC RESTRICTION; OXIDIZED PROTEINS; ESCHERICHIA-COLI; NEURODEGENERATIVE DISEASES; BRAIN PROTEINS; RAT-BRAIN; SACCHAROMYCES-CEREVISIAE;

D O I：

10.1002/mas.21375

中图分类号：

O433 [光谱学];

学科分类号：

070207 [光学];

摘要：

Detection and quantification of protein carbonyls present in biological samples has become a popular, albeit indirect, method to determine the existence of oxidative stress. Moreover, the rise of proteomics has allowed the identification of the specific proteins targeted by protein carbonylation. This review discusses these methodologies and proteomic strategies and then focuses on the relationship between protein carbonylation and aging and the parameters that may explain the increased sensitivity of certain proteins to protein carbonylation. (c) 2013 Wiley Periodicals, Inc. Rapid Commun. Mass Spectrom. 33: 21-48, 2014.

引用

页码：21 / 48

页数：28

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