Adenoviral disease in pediatric solid organ transplant recipients

被引：36

作者：

Hoffman, JA

机构：

[1] Childrens Hosp Los Angeles, Div Infect Dis, Los Angeles, CA 90027 USA

[2] Univ So Calif, Dept Pediat, Keck Sch Med, Los Angeles, CA 90089 USA

来源：

PEDIATRIC TRANSPLANTATION | 2006年 / 10卷 / 01期

关键词：

adenovirus; pediatric solid organ transplantation; polymerase chain reaction;

D O I：

10.1111/j.1399-3046.2006.00427.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Adenoviral disease in pediatric SOT recipients is emerging as an important viral pathogen, with serious consequences impacting morbidity, mortality and graft survival. The optimal diagnostic techniques, as well as therapy have yet to be established. This article reviews the current epidemiology of AdV in orthotopic liver, intestinal, cardiothoracic and renal transplant recipients. Issues related to diagnosis, notably the use of newer non-culture based viral detection methods and therapy, including anti-adenoviral agents and adoptive immunotherapy are discussed.

引用

收藏

页码：17 / 25

页数：9

相关论文

共 83 条

[21] Detection of adenovirus-specific T cells in children with adenovirus infection after allogeneic stem cell transplantation [J].

Feuchtinger, T ;

Lücke, J ;

Hamprecht, K ;

Richard, C ;

Handgretinger, R ;

Schumm, M ;

Greil, J ;

Bock, T ;

Niethammer, D ;

Lang, P .

BRITISH JOURNAL OF HAEMATOLOGY, 2005, 128 (04) :503-509

[22] Isolation and expansion of human adenovirus-specific CD4+ and CD8+ T cells according to IFN-γ secretion for adjuvant immunotherapy [J].

Feuchtinger, T ;

Lang, P ;

Hamprecht, K ;

Schumm, M ;

Greil, J ;

Jahn, G ;

Niethammer, D ;

Einsele, H .

EXPERIMENTAL HEMATOLOGY, 2004, 32 (03) :282-289

[23]

Flomenberg P, 1997, J MED VIROL, V51, P182, DOI 10.1002/(SICI)1096-9071(199703)51:3<182::AID-JMV7>3.0.CO

[24]

2-2

[25] INCREASING INCIDENCE OF ADENOVIRUS DISEASE IN BONE-MARROW TRANSPLANT RECIPIENTS [J].

FLOMENBERG, P ;

BABBITT, J ;

DROBYSKI, WR ;

ASH, RC ;

CARRIGAN, DR ;

SEDMAK, GV ;

MCAULIFFE, T ;

CAMITTA, B ;

HOROWITZ, MH ;

BUNIN, N ;

CASPER, JT .

JOURNAL OF INFECTIOUS DISEASES, 1994, 169 (04) :775-781

[26] Prevalence and quantitation of species C adenovirus DNA in human mucosal lymphocytes [J].

Garnett, CT ;

Erdman, D ;

Xu, W ;

Gooding, LR .

JOURNAL OF VIROLOGY, 2002, 76 (21) :10608-10616

[27] Intravenous ribavirin treatment for severe adenovirus disease in immunocompromised children [J].

Gavin, PJ ;

Katz, BZ .

PEDIATRICS, 2002, 110 (01) :e9

[28]

Green M, 2003, TRANSPLANT INFECT, P399

[29] Multiplexed, real-time PCR for quantitative detection of human adenovirus [J].

Gu, Z ;

Belzer, SW ;

Gibson, CS ;

Bankowski, MJ ;

Hayden, RT .

JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (10) :4636-4641

[30] Adenovirus infection after pediatric bone marrow transplantation [J].

Hale, GA ;

Heslop, HE ;

Krance, RA ;

Brenner, MA ;

Jayawardene, D ;

Srivastava, DK ;

Patrick, CC .

BONE MARROW TRANSPLANTATION, 1999, 23 (03) :277-282

← 1 2 3 4 5 6 7 8 9 →