SLAM receptors and SAP influence lymphocyte interactions, development and function

被引：168

作者：

Schwartzberg, Pamela L. ^{[1
]}

Mueller, Kristen L. ^{[1
]}

Qi, Hai ^{[2
]}

Cannons, Jennifer L. ^{[1
]}

机构：

[1] NHGRI, Bethesda, MD 20892 USA

[2] NIAID, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2009年 / 9卷 / 01期

关键词：

LINKED LYMPHOPROLIFERATIVE-DISEASE; T-CELL DEVELOPMENT; FOLLICULAR-HELPER-CELLS; BONE-MARROW-TRANSPLANTATION; B-CELLS; HUMORAL IMMUNITY; GENE-PRODUCT; MICE DEFICIENT; CUTTING EDGE; THYMOCYTE INTERACTION;

D O I：

10.1038/nri2456

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mutations that affect the adaptor molecule SLAM-associated protein (SAP) underlie the primary immunodeficiency disease X-linked lymphoproliferative syndrome. SAP is required for mediating signals from members of the signalling lymphocytic activation molecule (SLAM) family of immunomodulatory receptors. Recent data have highlighted a role for SAP in the development of innate-like T-cell lineages, including natural killer T cells, and in the regulation of the interactions between B cells and T cells that are required for germinal-centre formation and long-term humoral immunity. These data have revealed that SLAM family members and SAP have crucial roles in regulating lymphocyte interactions and adhesion, which are required for the normal development, homeostasis and function of the immune system.

引用

收藏

页码：39 / 46

页数：8

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