High expression of platelet-derived growth factor and transforming growth factor-β1 in blast cells from patients with Down Syndrome suffering from transient myeloproliferative disorder and organ fibrosis

被引：43

作者：

Hattori, H

Matsuzaki, A

Suminoe, A

Ihara, K

Nakayama, H

Hara, T

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Paediat, Higashi Ku, Fukuoka 8128582, Japan

[2] Kyushu Univ, Sch Hlth Sci, Div Child Hlth, Fukuoka 8128582, Japan

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2001年 / 115卷 / 02期

关键词：

platelet-derived growth factor (PDGF); transforming growth factor-beta 1 (TGF-beta 1); transient myeloproliferative disorder (TMD) acute megakaryoblastic leukaemia (AMKL); Down syndrome;

D O I：

10.1046/j.1365-2141.2001.03093.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To determine whether platelet-derived growth factor (PDGF) and transforming growth factor-beta1 (TGF-beta1) are involved in organ fibrosis in patients with transient myeloproliferative disorder (TMD) in Down syndrome, the expression of PDGF and TGF-beta1 mRNA in blast cells of TMD was investigated using real-time quantitative reverse transcription polymerase chain reaction. Blasts and liver tissue from TMD patients with hepatic fibrosis showed a significantly elevated expression of PDGF gene. The expression of TGF-beta1 gene was higher in TMD and acute megakaryoblastic leukaemia than in the control group. These results suggest that PDGF in combination with TGF-beta1 plays a role in organ fibrosis of TMD.

引用

页码：472 / 475

页数：4

共 14 条

[1] Immunohistochemical study on transforming growth factor-beta1 expression in liver fibrosis of Down's syndrome with transient abnormal myelopoiesis [J].