Synthesis of hydroxyapatite nanotubes for biomedical applications

被引：46

作者：

Chandanshive, Balasaheb B. ^{[1
]}

Rai, Priyanka ^{[2
]}

Rossi, Andre L. ^{[3
]}

Ersen, Ovidiu ^{[3
]}

Khushalani, Deepa ^{[1
]}

机构：

[1] Tata Inst Fundamental Res, Dept Chem Sci, Mat Chem Grp, Bombay 400005, Maharashtra, India

[2] Tata Inst Fundamental Res, Dept Biol Sci, Bombay 400005, Maharashtra, India

[3] IPCMS DSI, F-67034 Strasbourg 2, France

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2013年 / 33卷 / 05期

关键词：

Hydroxyapatite; Nanotubes; Alumina; Biomaterial; SPRAY-DRYING METHOD; HOLLOW MICROSPHERES; BONE; NANOSTRUCTURE; ADSORPTION; PHOSPHATE; DELIVERY;

D O I：

10.1016/j.msec.2013.03.022

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

082905 [生物质能源与材料]; 100103 [病原生物学];

摘要：

Single phase, stoichiometrically pure, hollow nanotubes of hydroxyapatite have been synthesized and single-particle analysis has been performed to successfully prove the sole formation of Ca-10(PO4)(6)(OH)(2) phase. The facile synthesis involves a sol-gel process under neutral conditions in the presence of a sacrifical anodic alumina template. The structures formed are hollow nanotubes that have been characterized by XRD, SEM, TEM, SAED, EELS, EDS and BET measurements. The diameter of the resulting tubes is in the range of 140-350 nm, length is on the order of a few microns and the wall thickness of the tubes was found to be ca. 30 nm. Moreover these tubes had a large BET surface area of 115 m(2)/g and were found to be biocompatible. They displayed inertness in the presence of NIH 3T3 mouse fibroblast cells as dictated by an MTT assay. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：2981 / 2986

页数：6

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