In vivo imaging of adult human hippocampal neurogenesis: progress, pitfalls and promise

被引：64

作者：

Ho, N. F. ^{[1
,2
,7
]}

Hooker, J. M. ^{[3
,7
]}

Sahay, A. ^{[4
,5
,6
,7
]}

Holt, D. J. ^{[1
,2
,7
]}

Roffman, J. L. ^{[1
,2
,7
]}

机构：

[1] Massachusetts Gen Hosp, Dept Psychiat, Schizophrenia Program, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Psychiat Neurosci Res Program, Charlestown, MA USA

[3] Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA

[4] Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA

[5] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA

[6] Harvard Stem Cell Inst, Boston, MA USA

[7] Harvard Univ, Sch Med, Boston, MA USA

来源：

MOLECULAR PSYCHIATRY | 2013年 / 18卷 / 04期

关键词：

Adult human hippocampal neurogenesis; in vivo neuroimaging; POSTTRAUMATIC-STRESS-DISORDER; NEURAL PROGENITOR CELLS; DENTATE GRANULE CELLS; VOXEL-BASED MORPHOMETRY; TERM LITHIUM TREATMENT; MEDIAL TEMPORAL-LOBE; RAT HIPPOCAMPUS; ELECTROCONVULSIVE SEIZURES; HUMAN BRAIN; ENRICHED ENVIRONMENT;

D O I：

10.1038/mp.2013.8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

New neurons are produced within the hippocampus of the mammalian brain throughout life. Evidence from animal studies has suggested that the function of these adult-born neurons is linked to cognition and emotion. Until we are able to detect and measure levels of adult neurogenesis in living human brains-a formidable challenge for now-we cannot establish its functional importance in human health, disease and new treatment development. Current non-invasive neuroimaging modalities can provide live snapshots of the brain's structure, chemistry, activity and connectivity. This review explores whether existing macroscopic imaging methods can be used to understand the microscopic dynamics of adult hippocampal neurogenesis in living individuals. We discuss recent studies that have found correlations between neuroimaging measures of human hippocampal biology and levels of pro- or anti-neurogenic stimuli, weigh whether these correlations reflect changes in adult neurogenesis, detail the conceptual and technical limitations of these studies and elaborate on what will be needed to validate in vivo neuroimaging measures of adult neurogenesis for future investigations. Molecular Psychiatry (2013) 18, 404-416; doi:10.1038/mp.2013.8; published online 26 February 2013

引用

页码：404 / 416

页数：13

共 169 条

[1]

AUTORADIOGRAPHIC AND HISTOLOGICAL EVIDENCE OF POSTNATAL HIPPOCAMPAL NEUROGENESIS IN RATS [J].