The Age of Olfactory Bulb Neurons in Humans

被引：300

作者：

Bergmann, Olaf ^{[1
]}

Liebl, Jakob ^{[4
]}

Bernard, Samuel ^{[5
]}

Alkass, Kanar ^{[2
]}

Yeung, Maggie S. Y. ^{[1
]}

Steier, Peter ^{[4
]}

Kutschera, Walter ^{[4
]}

Johnson, Lars ^{[3
]}

Landen, Mikael ^{[3
,6
]}

Druid, Henrik ^{[2
]}

Spalding, Kirsty L. ^{[1
]}

Frisen, Jonas ^{[1
]}

机构：

[1] Karolinska Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden

[2] Karolinska Inst, Dept Oncol Pathol, SE-17177 Stockholm, Sweden

[3] Karolinska Inst, Dept Clin Neurosci, Div Psychiat, SE-17177 Stockholm, Sweden

[4] Univ Vienna, Fac Phys Isotope Res, AT-1090 Vienna, Austria

[5] Univ Lyon, CNRS, UMR 5208, Inst Camille Jordan, FR-69622 Villeurbanne, France

[6] Gothenburg Univ, Sahlgrenska Acad, Inst Neurosci & Physiol, SE-40530 Gothenburg, Sweden

来源：

NEURON | 2012年 / 74卷 / 04期

基金：

瑞典研究理事会;

关键词：

NEURAL STEM-CELLS; ADULT HUMAN BRAIN; CHAIN MIGRATION; NUCLEAR TESTS; BOMB C-14; NEUROGENESIS; FOREBRAIN; DIFFERENTIATION; NEUROBLASTS; ACCELERATOR;

D O I：

10.1016/j.neuron.2012.03.030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Continuous turnover of neurons in the olfactory bulb is implicated in several key aspects of olfaction. There is a dramatic decline postnatally in the number of migratory neuroblasts en route to the olfactory bulb in humans, and it has been unclear to what extent the small number of neuroblasts at later stages contributes new neurons to the olfactory bulb. We have assessed the age of olfactory bulb neurons in humans by measuring the levels of nuclear bomb test-derived C-14 in genomic DNA. We report that C-14 concentrations correspond to the atmospheric levels at the time of birth of the individuals, establishing that there is very limited, if any, postnatal neurogenesis in the human olfactory bulb. This identifies a fundamental difference in the plasticity of the human brain compared to other mammals.

引用

页码：634 / 639

页数：6

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