Regulation of potassium channels by protein kinases

被引：165

作者：

Jonas, EA

Kaczmarek, LK

机构：

[1] Department of Pharmacology, Yale University, School of Medicine, New Haven, CT 06520

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1996年 / 6卷 / 03期

关键词：

D O I：

10.1016/S0959-4388(96)80114-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Studies of the role of protein phosphorylation in the modulation of neuronal excitability are beginning to identify specific sites on ion channels that are substrates for serine/threonine kinases and that contribute to short-term and long-term regulation of current amplitude and kinetics. In addition, it is becoming apparent that phosphorylation of tyrosine residues may produce acute changes in the characteristics of ion channels. These recent findings are best illustrated by examining the Shaker superfamily of potassium channels.

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页码：318 / 323

页数：6

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