New and potent inhibitors of nitric oxide synthase reduce motor activity in mice

被引：50

作者：

Dzoljic, E ^{[1
]}

DeVries, R ^{[1
]}

Dzoljic, MR ^{[1
]}

机构：

[1] UNIV BELGRADE, FAC MED, NEUROL INST, BELGRADE, YUGOSLAVIA

来源：

BEHAVIOURAL BRAIN RESEARCH | 1997年 / 87卷 / 02期

关键词：

3-bromo-7-nitro indazole; locomotion; mice; 7-nitro indazole; NO synthase inhibitors; S-methyl-L-thiocitrulline; 1-(2-trifluoromethylphenyl)imidazole;

D O I：

10.1016/S0166-4328(97)02281-X

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Potent inhibitors of nitric oxide synthase (NOS), 3-bromo-7-nitro indazole, 1-(2-trifluoromethylphenyl)imidazole, S-methyl-L-thiocitrulline and 7-nitro indazole, reduced locomotion in mice. These results suggest that activity of NOS and corresponding NO release are of importance for normal locomotion. (C) 1997 Elsevier Science B.V.

引用

页码：209 / 212

页数：4

共 28 条

[1] EFFECT OF NO SYNTHASE INHIBITION ON BEHAVIORAL-CHANGES INDUCED BY A SINGLE ADMINISTRATION OF METHAMPHETAMINE [J].

ABEKAWA, T ;

OHMORI, T ;

KOYAMA, T .

BRAIN RESEARCH, 1994, 666 (01) :147-150

[2] MOLECULAR ASPECTS OF NEUROPEPTIDE REGULATION AND FUNCTION IN THE CORPUS STRIATUM AND NUCLEUS-ACCUMBENS [J].

ANGULO, JA ;

MCEWEN, BS .

BRAIN RESEARCH REVIEWS, 1994, 19 (01) :1-28

[3] 7-NITRO INDAZOLE DERIVATIVES ARE POTENT INHIBITORS OF BRAIN, ENDOTHELIUM AND INDUCIBLE ISOFORMS OF NITRIC-OXIDE SYNTHASE [J].

BLANDWARD, PA ;

MOORE, PK .

LIFE SCIENCES, 1995, 57 (11) :PL131-PL135

[4] ENDOGENOUS NITRIC-OXIDE MODULATES MORPHINE-INDUCED CHANGES IN LOCOMOTION AND FOOD-INTAKE IN MICE [J].

CALIGNANO, A ;

PERSICO, P ;

MANCUSO, F ;

SORRENTINO, L .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 231 (03) :415-419

[5] POTENTIATION OF NMDA-MEDIATED TOXICITY ON NIGROSTRIATAL NEURONS BY A LOW-DOSE OF 7-NITRO INDAZOLE [J].

CONNOP, BP ;

ROLFE, NG ;

BOEGMAN, RJ ;

JHAMANDAS, K ;

BENINGER, RJ .

NEUROPHARMACOLOGY, 1994, 33 (11) :1439-1445

[6] NEOCORTICAL RHYTHMIC SLOW ACTIVITY DURING WAKEFULNESS AND PARADOXICAL SLEEP IN RATS [J].

DEPOORTERE, H .

NEUROPSYCHOBIOLOGY, 1987, 18 (03) :160-168

[7]

DZOLJIC E, 1996, SLEEP WAKE RES NETHE, V7, P53

[8] Sleep and nitric oxide: Effects of 7-nitro indazole, inhibitor of brain nitric oxide synthase [J].

Dzoljic, MR ;

deVries, R ;

vanLeeuwen, R .

BRAIN RESEARCH, 1996, 718 (1-2) :145-150

[9]

FURFINE ES, 1994, J BIOL CHEM, V269, P26677

[10]

GUEVARAGUZMAN R, 1994, J NEUROCHEM, V62, P807

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