New and potent inhibitors of nitric oxide synthase reduce motor activity in mice

被引：50

作者：

Dzoljic, E ^{[1
]}

DeVries, R ^{[1
]}

Dzoljic, MR ^{[1
]}

机构：

[1] UNIV BELGRADE, FAC MED, NEUROL INST, BELGRADE, YUGOSLAVIA

来源：

BEHAVIOURAL BRAIN RESEARCH | 1997年 / 87卷 / 02期

关键词：

3-bromo-7-nitro indazole; locomotion; mice; 7-nitro indazole; NO synthase inhibitors; S-methyl-L-thiocitrulline; 1-(2-trifluoromethylphenyl)imidazole;

D O I：

10.1016/S0166-4328(97)02281-X

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Potent inhibitors of nitric oxide synthase (NOS), 3-bromo-7-nitro indazole, 1-(2-trifluoromethylphenyl)imidazole, S-methyl-L-thiocitrulline and 7-nitro indazole, reduced locomotion in mice. These results suggest that activity of NOS and corresponding NO release are of importance for normal locomotion. (C) 1997 Elsevier Science B.V.

引用

页码：209 / 212

页数：4

共 28 条

[21] NITRIC-OXIDE RELEASES ACETYLCHOLINE IN THE BASAL FOREBRAIN [J].

PRAST, H ;

PHILIPPU, A .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 216 (01) :139-140

[22] L-NAME AND MK-801 ATTENUATE SENSITIZATION TO THE LOCOMOTOR-STIMULATING EFFECT OF COCAINE [J].

PUDIAK, CM ;

BOZARTH, MA .

LIFE SCIENCES, 1993, 53 (20) :1517-1524

[23] POSSIBLE INVOLVEMENT OF NITRIC-OXIDE IN CHLORDIAZEPOXIDE INDUCED ANXIOLYSIS IN MICE [J].

QUOCK, RM ;

NGUYEN, E .

LIFE SCIENCES, 1992, 51 (25) :PL255-PL260

[24] DECREASED SPONTANEOUS MOTOR-ACTIVITY AND STARTLE RESPONSE IN NITRIC-OXIDE SYNTHASE INHIBITOR-TREATED RATS [J].

SANDI, C ;

VENERO, C ;

GUAZA, C .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 277 (01) :89-97

[25] NITRIC-OXIDE AS A NEURONAL MESSENGER [J].

SNYDER, SH ;

BREDT, DS .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (04) :125-128

[26] DO NMDA RECEPTOR-MEDIATED CHANGES IN MOTOR BEHAVIOR INVOLVE NITRIC-OXIDE [J].

STARR, MS ;

STARR, BS .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 272 (2-3) :211-217

[27]

WITKIN JM, 1993, LIFE SCI, V53, pPL405

[28] EFFECT OF NITROPRUSSIDE (NITRIC-OXIDE) ON ENDOGENOUS DOPAMINE RELEASE FROM RAT STRIATAL SLICES [J].

ZHU, XZ ;

LUO, LG .

JOURNAL OF NEUROCHEMISTRY, 1992, 59 (03) :932-935

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