Omega-3 polyunsaturated fatty acids and chronic stress-induced modulations of glutamatergic neurotransmission in the hippocampus

被引:49
作者
Hennebelle, Marie [1 ]
Champeil-Potokar, Gaelle [2 ]
Lavialle, Monique [2 ]
Vancassel, Sylvie [3 ]
Denis, Isabelle [2 ]
机构
[1] Univ Sherbrooke, Dept Physiol & Biophys, Sherbrooke, PQ J1K 2R1, Canada
[2] INRA, Unite Nutr & Regulat Lipid Fonct Cerebrales, NuReLiCe, UR909, Jouy En Josas, France
[3] INRA, Unite Nutr & Neurobiol Integree, UMR1286, Bordeaux, France
关键词
astrocytes; chronic stress; DHA; glucocorticoids; glutamatergic synapse; neurons; LONG-TERM POTENTIATION; CHRONIC PSYCHOSOCIAL STRESS; GLUCOCORTICOID NEGATIVE FEEDBACK; PITUITARY-ADRENAL AXIS; DOCOSAHEXAENOIC ACID; RAT-BRAIN; SYNAPTIC PLASTICITY; DIETARY N-3; NEUROTROPHIC FACTOR; MESSENGER-RNA;
D O I
10.1111/nure.12088
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 [营养与食品卫生学];
摘要
Chronic stress causes the release of glucocorticoids, which greatly influence cerebral function, especially glutamatergic transmission. These stress-induced changes in neurotransmission could be counteracted by increasing the dietary intake of omega-3 polyunsaturated fatty acids (n-3 PUFAs). Numerous studies have described the capacity of n-3 PUFAs to help protect glutamatergic neurotransmission from damage induced by stress and glucocorticoids, possibly preventing the development of stress-related disorders such as depression or anxiety. The hippocampus contains glucocorticoid receptors and is involved in learning and memory. This makes it particularly sensitive to stress, which alters certain aspects of hippocampal function. In this review, the various ways in which n-3 PUFAs may prevent the harmful effects of chronic stress, particularly the alteration of glutamatergic synapses in the hippocampus, are summarized. (C) 2014 International Life Sciences Institute
引用
收藏
页码:99 / 112
页数:14
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