Regioselective addition of trimethylsilyl cyanide to E-1,1,1-trifluoro-4-ethoxybut-3-en-2-one

被引：20

作者：

Gerus, II ^{[1
]}

Kruchok, IS ^{[1
]}

Kukhar, VP ^{[1
]}

机构：

[1] Natl Acad Sci Ukraine, Inst Bioorgan Chem, UA-253660 Kiev 94, Ukraine

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 32期

关键词：

addition; trimethylsilyl cyanide; alpha; beta-unsaturated ketone; catalysis;

D O I：

10.1016/S0040-4039(99)01174-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 1,2- and 1,4-addition reactions of trimethylsilyl cyanide to 1,1,1-trifluoro-4-ethoxybut-3-en-2-one were studied. The regioselectivity of this reaction depends on the temperature, the nature of solvent and the catalyst. low temperatures or basic catalysts direct in favour of 1,2-addition while high temperatures or acidic catalysts direct in favour of 1,4-addition. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：5923 / 5926

页数：4

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