共 131 条
Microfluidics: Applications for analytical purposes in chemistry and biochemistry
被引:323
作者:

Ohno, Ken-ichi
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Analyt Sci, D-44139 Dortmund, Germany Inst Analyt Sci, D-44139 Dortmund, Germany

Tachikawa, Kaoru
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Analyt Sci, D-44139 Dortmund, Germany Inst Analyt Sci, D-44139 Dortmund, Germany

Manz, Andreas
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Analyt Sci, D-44139 Dortmund, Germany Inst Analyt Sci, D-44139 Dortmund, Germany
机构:
[1] Inst Analyt Sci, D-44139 Dortmund, Germany
关键词:
Integrated systems;
Multi-functionalisation;
Point-of-care;
Reaction;
Separation;
D O I:
10.1002/elps.200800121
中图分类号:
Q5 [生物化学];
学科分类号:
071010 ;
081704 ;
摘要:
In this review, we present recent advancements and novel developments in fluidic systems for applied analytical purposes in chemistry, biochemistry, and life science in general that employ and reflect the full benefits of microfluidics. A staggering rise in publications related to integrated, all-in-one microfluidic chips capable of separation, reaction, and detection have been observed, all of which realise the principal of micro total analysis systems or lab-on-a-chip. These integrated chips actively adopt the scaling law concepts, utilising the highly developed fabrication techniques. Their aim is to multi-functionalise and fully automate devices believed to assist the future advancements of point-of-care, clinical, and medical diagnostics.
引用
收藏
页码:4443 / 4453
页数:11
相关论文
共 131 条
[1]
A 768-lane microfabricated system for high-throughput DNA sequencing
[J].
Aborn, JH
;
El-Difrawy, SA
;
Novotny, M
;
Gismondi, EA
;
Lam, R
;
Matsudaira, P
;
Mckenna, BK
;
O'Neil, T
;
Streechon, P
;
Ehrlich, DJ
.
LAB ON A CHIP,
2005, 5 (06)
:669-674

Aborn, JH
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

El-Difrawy, SA
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Novotny, M
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Gismondi, EA
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Lam, R
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Matsudaira, P
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Mckenna, BK
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

O'Neil, T
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Streechon, P
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Ehrlich, DJ
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
[2]
Sensitive estimation of total cholesterol in blood using Au nanowires based micro-fluidic platform
[J].
Aravamudhan, Shyam
;
Kumar, Arun
;
Mohapatra, Shyam
;
Bhansali, Shekhar
.
BIOSENSORS & BIOELECTRONICS,
2007, 22 (9-10)
:2289-2294

Aravamudhan, Shyam
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Dept Elect Engn, BioMEMS, Tampa, FL 33620 USA

Kumar, Arun
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Dept Elect Engn, BioMEMS, Tampa, FL 33620 USA

Mohapatra, Shyam
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Dept Elect Engn, BioMEMS, Tampa, FL 33620 USA

Bhansali, Shekhar
论文数: 0 引用数: 0
h-index: 0
机构:
Univ S Florida, Dept Elect Engn, BioMEMS, Tampa, FL 33620 USA Univ S Florida, Dept Elect Engn, BioMEMS, Tampa, FL 33620 USA
[3]
Miniaturised nucleic acid analysis
[J].
Auroux, PA
;
Koc, Y
;
deMello, A
;
Manz, A
;
Day, PJR
.
LAB ON A CHIP,
2004, 4 (06)
:534-546

Auroux, PA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Manchester, CIGMR, Manchester M13 9PT, Lancs, England

Koc, Y
论文数: 0 引用数: 0
h-index: 0
机构: Univ Manchester, CIGMR, Manchester M13 9PT, Lancs, England

deMello, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Manchester, CIGMR, Manchester M13 9PT, Lancs, England

Manz, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Manchester, CIGMR, Manchester M13 9PT, Lancs, England

Day, PJR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Manchester, CIGMR, Manchester M13 9PT, Lancs, England
[4]
Detection of protein analytes via nanoparticle-based bio bar code technology
[J].
Bao, YP
;
Wei, TF
;
Lefebvre, PA
;
An, H
;
He, LX
;
Kunkel, GT
;
Müller, UR
.
ANALYTICAL CHEMISTRY,
2006, 78 (06)
:2055-2059

Bao, YP
论文数: 0 引用数: 0
h-index: 0
机构:
Nanosphere Inc, Northbrook, IL 60062 USA Nanosphere Inc, Northbrook, IL 60062 USA

Wei, TF
论文数: 0 引用数: 0
h-index: 0
机构:
Nanosphere Inc, Northbrook, IL 60062 USA Nanosphere Inc, Northbrook, IL 60062 USA

Lefebvre, PA
论文数: 0 引用数: 0
h-index: 0
机构:
Nanosphere Inc, Northbrook, IL 60062 USA Nanosphere Inc, Northbrook, IL 60062 USA

An, H
论文数: 0 引用数: 0
h-index: 0
机构:
Nanosphere Inc, Northbrook, IL 60062 USA Nanosphere Inc, Northbrook, IL 60062 USA

He, LX
论文数: 0 引用数: 0
h-index: 0
机构:
Nanosphere Inc, Northbrook, IL 60062 USA Nanosphere Inc, Northbrook, IL 60062 USA

Kunkel, GT
论文数: 0 引用数: 0
h-index: 0
机构:
Nanosphere Inc, Northbrook, IL 60062 USA Nanosphere Inc, Northbrook, IL 60062 USA

Müller, UR
论文数: 0 引用数: 0
h-index: 0
机构:
Nanosphere Inc, Northbrook, IL 60062 USA Nanosphere Inc, Northbrook, IL 60062 USA
[5]
Inline injection microdevice for attomole-scale sanger DNA sequencing
[J].
Blazej, Robert G.
;
Kumaresan, Palani
;
Cronier, Samantha A.
;
Mathies, Richard A.
.
ANALYTICAL CHEMISTRY,
2007, 79 (12)
:4499-4506

Blazej, Robert G.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Berkeley, UCSF UC Berkeley Joint Bioengn Grad Grp, Berkeley, CA 94720 USA

Kumaresan, Palani
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Berkeley, UCSF UC Berkeley Joint Bioengn Grad Grp, Berkeley, CA 94720 USA

Cronier, Samantha A.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Berkeley, UCSF UC Berkeley Joint Bioengn Grad Grp, Berkeley, CA 94720 USA

Mathies, Richard A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, UCSF UC Berkeley Joint Bioengn Grad Grp, Berkeley, CA 94720 USA Univ Calif Berkeley, UCSF UC Berkeley Joint Bioengn Grad Grp, Berkeley, CA 94720 USA
[6]
Miniaturized continuous flow reaction vessels: influence on chemical reactions
[J].
Brivio, M
;
Verboom, W
;
Reinhoudt, DN
.
LAB ON A CHIP,
2006, 6 (03)
:329-344

Brivio, M
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Twente, MESA Inst Nanotechnol, Lab Supramol Chem & Technol, NL-7500 AE Enschede, Netherlands Univ Twente, MESA Inst Nanotechnol, Lab Supramol Chem & Technol, NL-7500 AE Enschede, Netherlands

Verboom, W
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Twente, MESA Inst Nanotechnol, Lab Supramol Chem & Technol, NL-7500 AE Enschede, Netherlands Univ Twente, MESA Inst Nanotechnol, Lab Supramol Chem & Technol, NL-7500 AE Enschede, Netherlands

Reinhoudt, DN
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Twente, MESA Inst Nanotechnol, Lab Supramol Chem & Technol, NL-7500 AE Enschede, Netherlands Univ Twente, MESA Inst Nanotechnol, Lab Supramol Chem & Technol, NL-7500 AE Enschede, Netherlands
[7]
Electrophoretic manipulation of single DNA molecules in nanofabricated capillaries
[J].
Campbell, LC
;
Wilkinson, MJ
;
Manz, A
;
Camilleri, P
;
Humphreys, CJ
.
LAB ON A CHIP,
2004, 4 (03)
:225-229

Campbell, LC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Dept Mat Sci & Met, Cambridge CB2 3Q2, England

Wilkinson, MJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Dept Mat Sci & Met, Cambridge CB2 3Q2, England

Manz, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Dept Mat Sci & Met, Cambridge CB2 3Q2, England

Camilleri, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Dept Mat Sci & Met, Cambridge CB2 3Q2, England

Humphreys, CJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Dept Mat Sci & Met, Cambridge CB2 3Q2, England
[8]
High-sensitivity miniaturized immunoassays for tumor necrosis factor a using microfluidic systems
[J].
Cesaro-Tadic, S
;
Dernick, G
;
Juncker, D
;
Buurman, G
;
Kropshofer, H
;
Michel, B
;
Fattinger, C
;
Delamarche, E
.
LAB ON A CHIP,
2004, 4 (06)
:563-569

Cesaro-Tadic, S
论文数: 0 引用数: 0
h-index: 0
机构: IBM Res GmbH, Zurich Res Lab, CH-8803 Ruschlikon, Switzerland

Dernick, G
论文数: 0 引用数: 0
h-index: 0
机构: IBM Res GmbH, Zurich Res Lab, CH-8803 Ruschlikon, Switzerland

Juncker, D
论文数: 0 引用数: 0
h-index: 0
机构: IBM Res GmbH, Zurich Res Lab, CH-8803 Ruschlikon, Switzerland

Buurman, G
论文数: 0 引用数: 0
h-index: 0
机构: IBM Res GmbH, Zurich Res Lab, CH-8803 Ruschlikon, Switzerland

Kropshofer, H
论文数: 0 引用数: 0
h-index: 0
机构: IBM Res GmbH, Zurich Res Lab, CH-8803 Ruschlikon, Switzerland

Michel, B
论文数: 0 引用数: 0
h-index: 0
机构: IBM Res GmbH, Zurich Res Lab, CH-8803 Ruschlikon, Switzerland

Fattinger, C
论文数: 0 引用数: 0
h-index: 0
机构: IBM Res GmbH, Zurich Res Lab, CH-8803 Ruschlikon, Switzerland

Delamarche, E
论文数: 0 引用数: 0
h-index: 0
机构: IBM Res GmbH, Zurich Res Lab, CH-8803 Ruschlikon, Switzerland
[9]
Integrated polymerase chain reaction chips utilizing digital microfluidics
[J].
Chang, Yi-Hsien
;
Lee, Gwo-Bin
;
Huang, Fu-Chun
;
Chen, Yi-Yu
;
Lin, Jr-Lung
.
BIOMEDICAL MICRODEVICES,
2006, 8 (03)
:215-225

Chang, Yi-Hsien
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Cheng Kung Univ, Dept Engn Sci, Tainan 701, Taiwan Natl Cheng Kung Univ, Dept Engn Sci, Tainan 701, Taiwan

Lee, Gwo-Bin
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Cheng Kung Univ, Dept Engn Sci, Tainan 701, Taiwan Natl Cheng Kung Univ, Dept Engn Sci, Tainan 701, Taiwan

Huang, Fu-Chun
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Cheng Kung Univ, Dept Engn Sci, Tainan 701, Taiwan Natl Cheng Kung Univ, Dept Engn Sci, Tainan 701, Taiwan

Chen, Yi-Yu
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Cheng Kung Univ, Dept Engn Sci, Tainan 701, Taiwan Natl Cheng Kung Univ, Dept Engn Sci, Tainan 701, Taiwan

Lin, Jr-Lung
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Cheng Kung Univ, Dept Engn Sci, Tainan 701, Taiwan Natl Cheng Kung Univ, Dept Engn Sci, Tainan 701, Taiwan
[10]
Semihydrodynamic injection for high salt stacking and sweeping on microchip electrophoresis and its application for the analysis of estrogen and estrogen binding
[J].
Chen, g-Chuan Chen
;
Yen, Shu-Fang
;
Makamba, Honest
;
Li, Chun-Wei
;
Tsai, Mei-Ling
;
Chen, Shu-Hui
.
ANALYTICAL CHEMISTRY,
2007, 79 (01)
:195-201

Chen, g-Chuan Chen
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan

Yen, Shu-Fang
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan

Makamba, Honest
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan

Li, Chun-Wei
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan

Tsai, Mei-Ling
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan

Chen, Shu-Hui
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan