Asthma: beyond corticosteroid treatment

被引：18

作者：

Marandi, Yasser ^{[1
]}

Farahi, Neda ^{[2
]}

Hashjin, Goudarz Sadeghi ^{[3
]}

机构：

[1] Ahvaz Jundishapur Univ Med Sci, Dept Pharmacol, Ahvaz, Iran

[2] Univ Cambridge, Sch Clin Med, Div Resp Med, Cambridge, England

[3] Univ Tehran, Fac Vet Med, Tehran 14155, Iran

来源：

ARCHIVES OF MEDICAL SCIENCE | 2013年 / 9卷 / 03期

关键词：

asthma; corticosteroids; inflammation; FLUTICASONE FUROATE; ALLERGEN CHALLENGE; KINASE INHIBITOR; R-ROSCOVITINE; DOUBLE-BLIND; IN-VIVO; ANTIBODY; BLOCKADE; HYPERRESPONSIVENESS; EXACERBATIONS;

D O I：

10.5114/aoms.2013.33179

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. It is an inflammatory disorder characterized by bronchoconstriction and airway hyperresponsiveness, followed by inflammatory manifestations in the respiratory system. The prevalence of asthma is rising and there is a clinical need to develop more effective treatments. While corticosteroids (glucocorticosteroids) remain the mainstay of asthma therapy, they have limitations because of their potentially severe side-effects and the presence of corticosteroid resistance in some patients. This review discusses current strategies in the treatment of asthma and considers new therapeutic regimens of asthma in the drug development pipeline.

引用

页码：521 / 526

页数：6

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