Comparison of performance in two diagnostic methods for tuberculosis infection

被引：32

作者：

Higuchi, Kazue ^{[1
]}

Kawabe, Yoshiko ^{[2
]}

Mitarai, Satoshi ^{[1
]}

Yoshiyama, Takashi ^{[3
]}

Harada, Nobuyuki ^{[1
]}

Mori, Toru ^{[1
]}

机构：

[1] Japan AntiTB Assoc, Res Inst TB, Div Immunol, Tokyo 2048533, Japan

[2] Natl Hosp Org Tokyo Hosp, Tokyo 2048585, Japan

[3] Fukujuji Hosp, Tokyo 2048522, Japan

来源：

MEDICAL MICROBIOLOGY AND IMMUNOLOGY | 2009年 / 198卷 / 01期

关键词：

Interferon-gamma; Tuberculosis; Diagnosis; ESAT-6; CFP-10; INTERFERON-GAMMA ASSAYS; MYCOBACTERIUM-TUBERCULOSIS; RAPID DETECTION; RELEASE ASSAYS; T-CELLS; ENUMERATION; DISEASE; INDIVIDUALS; TESTS;

D O I：

10.1007/s00430-008-0102-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Performance of two diagnoses, T-SPOTA (R).TB (T-SPOT) and QuantiFERON-TBA (R) Gold (QFT-G), was compared in Japanese subjects. Forty-seven confirmed tuberculosis patients and eighty-four healthy subjects were recruited. All samples were assessed for both T-SPOT and QFT-G, and the sensitivities and the specificities were compared between two methods. The sensitivity was 100% for T-SPOT, and 87.2% for QFT-G. The specificity was 83.3 and 98.8%, respectively. The overall agreement of two tests was substantially high (Kappa coefficient = 0.671). The sensitivity of T-SPOT appeared to be higher than that of QFT-G, whereas the specificity of T-SPOT was significantly lower than that of QFT-G. The difference in the performance between T-SPOT and QFT-G and biological relevance of each system in diagnosing M. tuberculosis infection should be further explored.

引用

页码：33 / 37

页数：5

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