Telomere length maintenance - an ALTernative mechanism

被引：25

作者：

Royle, N. J. ^{[1
]}

Foxon, J. ^{[1
]}

Jeyapalan, J. N. ^{[1
]}

Mendez-Bermudez, A. ^{[1
]}

Novo, C. L. ^{[1
]}

Williams, J. ^{[1
]}

Cotton, V. E. ^{[1
]}

机构：

[1] Univ Leicester, Dept Genet, Leicester LE1 7RH, Leics, England

来源：

CYTOGENETIC AND GENOME RESEARCH | 2008年 / 122卷 / 3-4期

关键词：

D O I：

10.1159/000167814

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Alternative Lengthening of Telomeres (ALT) mechanism is utilised by approximately 10% of human tumours and a higher proportion of some types of sarcomas. ALT+ cell lines and tumours show heterogeneous telomere length, extra-chromosomal circular and linear telomeric DNA, ALT associated promyelocytic bodies (APBs), a high frequency of post-replication exchanges in telomeres (designated as telomere-sister chromatid exchanges, T-SCE) and high instability at a GC-rich minisatellite, MS32 (D1S8). It is clear that there is a link between the minisatellite instability and the mechanism that underpins ALT, however currently the nature of this relationship is uncertain. Single molecule analysis of telomeric DNA from ALT+ cell lines and tumours has revealed complex telomere mutations that have not been seen in cell lines or tumours that express telomerase. These complex telomere mutations cannot be explained by T-SCE but must arise by another inter-molecular process. The break-induced replication (BIR) model that may explain the observed high frequency of T-SCE and the presence of complex telomere mutations is reviewed. Copyright (C) 2008 S. Karger AG, Basel

引用

页码：281 / 291

页数：11

共 108 条

[41] Alternative lengthening of telomeres in mammalian cells [J].

Henson, JD ;

Neumann, AA ;

Yeager, TR ;

Reddel, RR .

ONCOGENE, 2002, 21 (04) :598-610

[42] Mutation mechanisms that underlie turnover of a human telomere-adjacent segmental duplication containing an unstable minisatellite [J].

Hills, Mark ;

Jeyapalan, Jennie N. ;

Foxon, Jennifer L. ;

Royle, Nicola J. .

GENOMICS, 2007, 89 (04) :480-489

[43] POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end [J].

Hockemeyer, D ;

Sfeir, AJ ;

Shay, JW ;

Wright, WE ;

de Lange, T .

EMBO JOURNAL, 2005, 24 (14) :2667-2678

[44] Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres [J].

Hockemeyer, Dirk ;

Daniels, Jan-Peter ;

Takai, Hiroyuki ;

de Lange, Titia .

CELL, 2006, 126 (01) :63-77

[45] COMPLEX GENE CONVERSION EVENTS IN GERMLINE MUTATION AT HUMAN MINISATELLITES [J].

JEFFREYS, AJ ;

TAMAKI, K ;

MACLEOD, A ;

MONCKTON, DG ;

NEIL, DL ;

ARMOUR, JAL .

NATURE GENETICS, 1994, 6 (02) :136-145

[46] Somatic mutation processes at a human minisatellite [J].

Jeffreys, AJ ;

Neumann, R .

HUMAN MOLECULAR GENETICS, 1997, 6 (01) :129-136

[47] REPEAT UNIT SEQUENCE VARIATION IN MINISATELLITES - A NOVEL SOURCE OF DNA POLYMORPHISM FOR STUDYING VARIATION AND MUTATION BY SINGLE MOLECULE ANALYSIS [J].

JEFFREYS, AJ ;

NEUMANN, R ;

WILSON, V .

CELL, 1990, 60 (03) :473-485

[48] High-resolution mapping of crossovers in human sperm defines a minisatellite-associated recombination hotspot [J].

Jeffreys, AJ ;

Murray, J ;

Neumann, R .

MOLECULAR CELL, 1998, 2 (02) :267-273

[49] Evidence for alternative lengthening of telomeres in liposarcomas in the absence of ALT-associated PML bodies [J].

Jeyapalan, Jennie N. ;

Mendez-Bermudez, Aaron ;

Zaffaroni, Nadia ;

Dubrova, Yuri E. ;

Royle, Nicola J. .

INTERNATIONAL JOURNAL OF CANCER, 2008, 122 (11) :2414-2421

[50] Activation of the ALT pathway for telomere maintenance can affect other sequences in the human genome [J].

Jeyapalan, JN ;

Varley, H ;

Foxon, JL ;

Pollock, RE ;

Jeffreys, AJ ;

Henson, JD ;

Reddel, RR ;

Royle, NJ .

HUMAN MOLECULAR GENETICS, 2005, 14 (13) :1785-1794

← 1 2 3 4 5 6 7 8 9 10 →