Bioprospecting Marine Plankton

被引:45
作者
Abida, Heni [1 ]
Ruchaud, Sandrine [2 ]
Rios, Laurent [3 ]
Humeau, Anne [4 ]
Probert, Ian [5 ]
De Vargas, Colomban [6 ]
Bach, Stephane [2 ]
Bowler, Chris [1 ]
机构
[1] CNRS, INSERM U1024 UMR8197, IBENS, Environm & Evolutionary Genom Sect, F-75230 Paris 05, France
[2] CNRS, KISSf, Stn Biol Roscoff, USR Prot Phosphorylat & Human Dis 3151, F-29688 Roscoff, France
[3] Greentech France, Biopole Clermont Limagne, F-63360 St Beauzire, France
[4] Soliance France, Ctr Marine Biotechnol, Anse Pors Gelin Ile Grande, F-22560 Plemeur Bodou, France
[5] CNRS, USR 3151, Stn Biol Roscoff, Roscoff Culture Collect, F-29688 Roscoff, France
[6] CNRS, USR 3151, Stn Biol Roscoff, EPPO Lab, F-29688 Roscoff, France
关键词
bioprospecting; high-throughput screening; plankton natural product; marine natural product; biodiversity; molecule discovery; METABOLITES; MICROALGAE; LARVAE; SEA; ANTIBIOTICS; FUCOXANTHIN; EMERGENCE; SELECTION; DEFENSE; SYSTEM;
D O I
10.3390/md11114594
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The ocean dominates the surface of our planet and plays a major role in regulating the biosphere. For example, the microscopic photosynthetic organisms living within provide 50% of the oxygen we breathe, and much of our food and mineral resources are extracted from the ocean. In a time of ecological crisis and major changes in our society, it is essential to turn our attention towards the sea to find additional solutions for a sustainable future. Remarkably, while we are overexploiting many marine resources, particularly the fisheries, the planktonic compartment composed of zooplankton, phytoplankton, bacteria and viruses, represents 95% of marine biomass and yet the extent of its diversity remains largely unknown and underexploited. Consequently, the potential of plankton as a bioresource for humanity is largely untapped. Due to their diverse evolutionary backgrounds, planktonic organisms offer immense opportunities: new resources for medicine, cosmetics and food, renewable energy, and long-term solutions to mitigate climate change. Research programs aiming to exploit culture collections of marine micro-organisms as well as to prospect the huge resources of marine planktonic biodiversity in the oceans are now underway, and several bioactive extracts and purified compounds have already been identified. This review will survey and assess the current state-of-the-art and will propose methodologies to better exploit the potential of marine plankton for drug discovery and for dermocosmetics.
引用
收藏
页码:4594 / 4611
页数:18
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