Phenothiazines: potential alternatives for the management of antibiotic resistant infections of tuberculosis and malaria in developing countries

被引:54
作者
Amaral, L [1 ]
Viveiros, M
Kristiansen, JE
机构
[1] Univ Nova Lisboa, Inst Hyg & Trop Med, Unit Mycobacteriol, P-1349008 Lisbon, Portugal
[2] S Danish Univ, Sonderborg Sygehus, Dept Clin Microbiol, Sonderborg, Denmark
关键词
phenothiazines; antimicrobial activity; tuberculosis; malaria;
D O I
10.1046/j.1365-3156.2001.00804.x
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The in vitro and in vivo activity of phenothiazines against antibiotic Susceptible and antibiotic resistant Mycobacterium tuberculosis and malaria-causing Plasmodia is reviewed. Given the facts that Pulmonary tuberculosis and malaria are the major causes of death in developing Countries, that both of these infections continue to escalate in their resistance to antibiotics, that the cost for the management of these infections is beyond that afforded by most developing nations, and lastly, that new and effective agents are not forthcoming from the pharmaceutical industry, the scientific rationale for the potential use of select phenothiazines for the management of these infections is presented.
引用
收藏
页码:1016 / 1022
页数:7
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