Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations

被引：11

作者：

Newton, PN

Ward, S

Angus, BJ

Chierakul, W

Dondorp, A

Ruangveerayuth, R

Silamut, K

Teerapong, P

Suputtamongkol, Y

Looareesuwan, S

White, NJ

机构：

[1] Mahidol Univ, Fac Trop Med, Bangkok 10400, Thailand

[2] Churchill Hosp, Nuffield Dept Clin Med, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7LJ, England

[3] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England

[4] Mae Sot Hosp, Mae Sot, Tak, Thailand

[5] Mahidol Univ, Dept Pharmacol, Bangkok 10700, Thailand

[6] Siriraj Hosp, Dept Med, Bangkok, Thailand

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2006年 / 100卷 / 02期

基金：

英国惠康基金;

关键词：

malaria; Plasmodium falciparum; quinine; pharmacokinetics; treatment failure; Thailand;

D O I：

10.1016/j.trstmh.2005.01.008

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria. (C) 2005 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

引用

页码：184 / 186

页数：3

共 17 条

[11]

PINSWADI K, 1965, J MED ASS THAI, V48, P386

[12] Quinine pharmacokinetic-pharmacodynamic relationships in uncomplicated falciparum malaria [J].