Systems biology - Metabonomics

被引：1546

作者：

Nicholson, Jeremy K. ^{[1
]}

Lindon, John C. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Biomol Med, London SW7 2AZ, England

来源：

NATURE | 2008年 / 455卷 / 7216期

关键词：

D O I：

10.1038/4551054a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Organisms often respond in complex and unpredictable ways to stimuli that cause disease or injury. By measuring and mathematically modelling changes in the levels of products of metabolism found in biological fluids and tissues, metabonomics offers fresh insight into the effects of diet, drugs and disease.

引用

页码：1054 / 1056

页数：3

共 6 条

[1] An ecological and evolutionary perspective on human-microbe mutualism and disease [J].

Dethlefsen, Les ;

McFall-Ngai, Margaret ;

Relman, David A. .

NATURE, 2007, 449 (7164) :811-818

[2] Metabolic phenotyping in health and disease [J].

Holmes, Elaine ;

Wilson, Ian D. ;

Nicholson, Jeremy K. .

CELL, 2008, 134 (05) :714-717

[3] Human metabolic phenotype diversity and its association with diet and blood pressure [J].

Holmes, Elaine ;

Loo, Ruey Leng ;

Stamler, Jeremiah ;

Bictash, Magda ;

Yap, Ivan K. S. ;

Chan, Queenie ;

Ebbels, Tim ;

De Iorio, Maria ;

Brown, Ian J. ;

Veselkov, Kirill A. ;

Daviglus, Martha L. ;

Kesteloot, Hugo ;

Ueshima, Hirotsugu ;

Zhao, Liancheng ;

Nicholson, Jeremy K. ;

Elliott, Paul .

NATURE, 2008, 453 (7193) :396-U50

[4] Analytical strategies in metabonomics [J].

Lenz, Eva Maria ;

Wilson, Ian D. .

JOURNAL OF PROTEOME RESEARCH, 2007, 6 (02) :443-458

[5] Understanding 'global' systems biology: Metabonomics and the continuum of metabolism [J].

Nicholson, JK ;

Wilson, ID .

NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (08) :668-676

[6] HMDB: the human metabolome database [J].

Wishart, David S. ;

Tzur, Dan ;

Knox, Craig ;

Eisner, Roman ;

Guo, An Chi ;

Young, Nelson ;

Cheng, Dean ;

Jewell, Kevin ;

Arndt, David ;

Sawhney, Summit ;

Fung, Chris ;

Nikolai, Lisa ;

Lewis, Mike ;

Coutouly, Marie-Aude ;

Forsythe, Ian ;

Tang, Peter ;

Shrivastava, Savita ;

Jeroncic, Kevin ;

Stothard, Paul ;

Amegbey, Godwin ;

Block, David ;

Hau, David D. ;

Wagner, James ;

Miniaci, Jessica ;

Clements, Melisa ;

Gebremedhin, Mulu ;

Guo, Natalie ;

Zhang, Ying ;

Duggan, Gavin E. ;

MacInnis, Glen D. ;

Weljie, Alim M. ;

Dowlatabadi, Reza ;

Bamforth, Fiona ;

Clive, Derrick ;

Greiner, Russ ;

Li, Liang ;

Marrie, Tom ;

Sykes, Brian D. ;

Vogel, Hans J. ;

Querengesser, Lori .

NUCLEIC ACIDS RESEARCH, 2007, 35 :D521-D526

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