Apoptosis in placentas from human T-lymphotropic virus type I-seropositive pregnant women: A possible defense mechanism against transmission from mother to fetus

被引:9
作者
Fujino, T
Iwamoto, I
Otsuka, H
Ikeda, T
Takesako, S
Nagata, Y
机构
[1] Kagoshima Univ, Sch Hlth Sci, Kagoshima 8908506, Japan
[2] Kagoshima Univ, Dept Obstet & Gynecol, Fac Med, Kagoshima 8908506, Japan
关键词
D O I
10.1016/S0029-7844(99)00322-1
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: The mechanism by which the placenta serves as the barrier against mother-to-fetus transmission of microorganisms remains to be elucidated. Programmed cell death, apoptosis, is considered a cellular defense mechanism against infection. The hypothesis of this study is that apoptosis of human T-lymphotropic virus type I (HTLV-I)infected placental villous cells is involved in the defense mechanism against mother-to-fetus transmission of HTLV-I. Methods: Apoptosis was compared in term placentas from eight HTLV-I-seropositive pregnant women and eight HTLV-I-seronegative pregnant women by the terminal deoxynucleotidyl transferase-mediated deoxyuridine nick end-labeling method. In addition, an in vitro cocultivation with an HTLV-I-infected lymphocyte cell line (MT-2 cells) was performed to examine whether placental villous cells were infected with HTLV-I and apoptosis was induced. Results: The incidence of apoptosis-positive cells (nuclei) in placentas from the HTLV-I-seropositive pregnant women was higher than in the HTLV-I-seronegative pregnant women (P < .02). Cocultivation with MT-2 cells showed that trophoblast cells were able to be infected with HTLV-I and that apoptosis was induced in the placental villous cells. Conclusion: HTLV-I infection induces apoptosis in the placenta. We speculate that apoptosis may be involved in the defense mechanism of the placenta against mother-to-fetus transmission of HTLV-I. (C) 1999 by The American College of Obstetricians and Gynecologists.
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页码:279 / 283
页数:5
相关论文
共 18 条
[11]   MONOCLONAL-ANTIBODY TO CYTOKERATIN FOR USE IN ROUTINE HISTOPATHOLOGY [J].
MAKIN, CA ;
BOBROW, LG ;
BODMER, WF .
JOURNAL OF CLINICAL PATHOLOGY, 1984, 37 (09) :975-983
[12]  
MIYOSHI I, 1981, GANN, V72, P978
[13]  
SAITO S, 1992, JPN J CANCER RES, V39, P175
[14]   Placental apoptosis in normal human pregnancy [J].
Smith, SC ;
Baker, PN ;
Symonds, EM .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1997, 177 (01) :57-65
[15]   MECHANISMS AND GENES OF CELLULAR SUICIDE [J].
STELLER, H .
SCIENCE, 1995, 267 (5203) :1445-1449
[16]  
TANAKA Y, 1983, JPN J CANCER RES, V74, P327
[17]   APOPTOSIS IN THE PATHOGENESIS AND TREATMENT OF DISEASE [J].
THOMPSON, CB .
SCIENCE, 1995, 267 (5203) :1456-1462
[18]   MONONUCLEAR PHAGOCYTES IN THE HUMAN-PLACENTA [J].
WOOD, GW .
PLACENTA, 1980, 1 (02) :113-123