Important discoveries from analysing bacterial phenotypes

被引：40

作者：

Bochner, Barry R. ^{[1
]}

Giovannetti, Luciana ^{[2
]}

Viti, Carlo ^{[2
]}

机构：

[1] Biolog Inc, Hayward, CA 94545 USA

[2] Univ Florence, Dipartimento Biotecnol Agr, I-50144 Florence, Italy

来源：

MOLECULAR MICROBIOLOGY | 2008年 / 70卷 / 02期

关键词：

D O I：

10.1111/j.1365-2958.2008.06383.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability to test hundreds to thousands of cellular phenotypes in a single experiment has opened up new avenues of investigation and exploration and led to important discoveries in very diverse applications of microbiological research and development. The information provided by global phenotyping is complementary to, and often more easily interpretable than information provided by global molecular analytical methods such as gene chips and proteomics. This report summarizes advances presented by scientists brought together to share their experiences and knowledge gained with high-throughput phenotyping.

引用

收藏

页码：274 / 280

页数：7

相关论文

共 29 条

[1] New technologies to assess genotype-phenotype relationships [J].

Bochner, BR .

NATURE REVIEWS GENETICS, 2003, 4 (04) :309-314

[2] Phenotype MicroArrays for high-throughput phenotypic testing and assay of gene function [J].

Bochner, BR ;

Gadzinski, P ;

Panomitros, E .

GENOME RESEARCH, 2001, 11 (07) :1246-1255

[3] Genome plasticity of BCG and impact on vaccine efficacy [J].

Brosch, Roland ;

Gordon, Stephen V. ;

Garnier, Thierry ;

Eiglmeier, Karin ;

Frigui, Wafa ;

Valenti, Philippe ;

Dos Santos, Sandrine ;

Duthoy, Stephanie ;

Lacroix, Celine ;

Garcia-Pelayo, Carmen ;

Inwald, Jacqueline K. ;

Golby, Paul ;

Garcia, Javier Nunez ;

Hewinson, R. Glyn ;

Behr, Marcel A. ;

Quail, Michael A. ;

Churcher, Carol ;

Barrell, Bart G. ;

Parkhill, Julian ;

Cole, Stewart T. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (13) :5596-5601

[4] Integrating high-throughput and computational data elucidates bacterial networks [J].

Covert, MW ;

Knight, EM ;

Reed, JL ;

Herrgard, MJ ;

Palsson, BO .

NATURE, 2004, 429 (6987) :92-96

[5] Global carbon utilization profiles of wild-type, mutant, and transformant strains of Hypocrea jecorina [J].

Druzhinina, IS ;

Schmoll, M ;

Seiboth, B ;

Kubicek, CP .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2006, 72 (03) :2126-2133

[6] Comparison of carbon nutrition for pathogenic and commensal Escherichia coli strains in the mouse intestine [J].

Fabich, Andrew J. ;

Jones, Shari A. ;

Chowdhury, Fatema Z. ;

Cernosek, Amanda ;

Anderson, April ;

Smalley, Darren ;

McHargue, J. Wesley ;

Hightower, G. Aaron ;

Smith, Joel T. ;

Autieri, Steven M. ;

Leatham, Mary P. ;

Lins, Jeremy J. ;

Allen, Regina L. ;

Laux, David C. ;

Cohen, Paul S. ;

Conway, Tyrrell .

INFECTION AND IMMUNITY, 2008, 76 (03) :1143-1152

[7] A genome-scale metabolic reconstruction for Escherichia coli K-12 MG1655 that accounts for 1260 ORFs and thermodynamic information [J].

Feist, Adam M. ;

Henry, Christopher S. ;

Reed, Jennifer L. ;

Krummenacker, Markus ;

Joyce, Andrew R. ;

Karp, Peter D. ;

Broadbelt, Linda J. ;

Hatzimanikatis, Vassily ;

Palsson, Bernhard O. .

MOLECULAR SYSTEMS BIOLOGY, 2007, 3

[8] Photostimulation of Hypocrea atroviridis growth occurs due to a cross-talk of carbon metabolism, blue light receptors and response to oxidative stress [J].

Friedl, Martina A. ;

Schmoll, Monika ;

Kubicek, Christian P. ;

Druzhinina, Irina S. .

MICROBIOLOGY-SGM, 2008, 154 :1229-1241

[9] Carbon source dependence and photostimulation of conidiation in Hypocrea atrovifidis [J].

Friedl, Martina A. ;

Kubicek, Christian P. ;

Druzhinina, Irina S. .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2008, 74 (01) :245-250

[10] Subpopulation characteristics of egg-contaminating Salmonella enterica serovar enteritidis as defined by the lipopolysaccharide O chain [J].

Guard-Bouldin, J ;

Gast, RK ;

Humphrey, TJ ;

Henzler, DJ ;

Morales, C ;

Coles, K .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2004, 70 (05) :2756-2763