Approach to green chemistry of DMT-MM: recovery and recycle of coproduct to chloromethane-free DMT-MM

被引：39

作者：

Kunishima, M ^{[1
]}

Hioki, K

Wada, A

Kobayashi, H

Tani, S

机构：

[1] Kobe Gakuin Univ, Fac Pharmaceut Sci, Nishi Ku, Kobe, Hyogo 6512180, Japan

[2] Kobe Gakuin Univ, High Technol Res Ctr, Nishi Ku, Kobe, Hyogo 6512180, Japan

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 18期

关键词：

triazines; condensation; amides;

D O I：

10.1016/S0040-4039(02)00546-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple procedure for the isolation of 2-hydroxy-4,6-dimethoxy-1,3,5-triazine (HO-DMT), a coproduct arising from dehydrating condensation using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM) has been established. HO-DMT can be recycled by treatment with POCI3 to give 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT), which is further converted to DMT-MM. Alternatively, reaction with traflic anhydride followed by addition of N-methylmorpholine gives DMT-MM triflate. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3323 / 3326

页数：4

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