Approach to green chemistry of DMT-MM: recovery and recycle of coproduct to chloromethane-free DMT-MM

被引:39
作者
Kunishima, M [1 ]
Hioki, K
Wada, A
Kobayashi, H
Tani, S
机构
[1] Kobe Gakuin Univ, Fac Pharmaceut Sci, Nishi Ku, Kobe, Hyogo 6512180, Japan
[2] Kobe Gakuin Univ, High Technol Res Ctr, Nishi Ku, Kobe, Hyogo 6512180, Japan
关键词
triazines; condensation; amides;
D O I
10.1016/S0040-4039(02)00546-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A simple procedure for the isolation of 2-hydroxy-4,6-dimethoxy-1,3,5-triazine (HO-DMT), a coproduct arising from dehydrating condensation using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM) has been established. HO-DMT can be recycled by treatment with POCI3 to give 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT), which is further converted to DMT-MM. Alternatively, reaction with traflic anhydride followed by addition of N-methylmorpholine gives DMT-MM triflate. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:3323 / 3326
页数:4
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