Microtubule polyglutamylation in Drosophila melanogaster brain and testis

被引：17

作者：

Bobinnec, Y ^{[1
]}

Marcaillou, C ^{[1
]}

Debec, A ^{[1
]}

机构：

[1] Univ Paris 06, Lab Physiol Cellulaire Invertebres, F-75005 Paris, France

来源：

EUROPEAN JOURNAL OF CELL BIOLOGY | 1999年 / 78卷 / 09期

关键词：

tubulin posttranslational modification; tubulin glutamylation; microtubules; flagella;

D O I：

10.1016/S0171-9335(99)80053-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The presence of glutamylated tubulin, a widespread posttranslational modification of alpha- and beta-tubulin, has been investigated in Drosophila melanogaster using the specific monoclonal antibody GT335. We show here that this modification is strongly detected in brain and testis whereas other tissues analyzed did not appear to contain any glutamylated isoforms. Neuronal microtubules are glutamylated on alpha-tubulin only whereas sperm flagella showed a strong modification of both alpha- and beta-tubulin. These results argue for an essential role for glutamylation in differentiation processes that require microtubule stabilization.

引用

页码：671 / 674

页数：4

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