E-Cadherin/Catenin Complexes Are Formed Cotranslationally in the Endoplasmic Reticulum/Golgi Compartments

被引：27

作者：

Curtis, Matthew W. ^{[1
]}

Johnson, Keith R. ^{[1
,2
,3
,4
,5
]}

Wheelock, Margaret J. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Nebraska, Med Ctr, Dept Pathol, Omaha, NE 68198 USA

[2] Univ Nebraska, Med Ctr, Dept Microbiol, Omaha, NE 68198 USA

[3] Univ Nebraska, Med Ctr, Dept Oral Biol, Omaha, NE 68198 USA

[4] Univ Nebraska, Med Ctr, Eppley Inst Res Canc & Allied Dis, Omaha, NE 68198 USA

[5] Univ Nebraska, Med Ctr, Eppley Canc Ctr, Omaha, NE 68198 USA

来源：

CELL COMMUNICATION AND ADHESION | 2008年 / 15卷 / 04期

关键词：

E-cadherin; prosequence; catenin; N-cadherin; Golgi complex; adhesion;

D O I：

10.1080/15419060802460748

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cadherins are synthesized with a proregion that lies between a short amino-terminal signal sequence and the first extracellular domain. Following synthesis, the proregion is cleaved, an event that is mandatory for the mature cadherin to function in adhesion. The authors have previously reported that catenins coimmunoprecipate with pro-N-cadherin, and that the N-cadherin/catenin complex forms in the Golgi/endoplasmic reticulum. It is clear that N- and E-cadherin confer significantly different characteristics on cells, and it is possible that N- and E-cadherin/catenin complex formation is equally different. To investigate this, the authors generated an antibody against the proregion of E-cadherin and have used it to examine the assembly of the E-cadherin/catenin complex.

引用

页码：365 / 378

页数：14

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