High-Efficiency Loading and Controlled Release of Doxorubicin Hydrochloride on Graphene Oxide

被引：876

作者：

Yang, Xiaoying ^{[1
]}

Zhang, Xiaoyan ^{[2
,3
]}

Liu, Zunfeng ^{[2
,3
]}

Ma, Yanfeng ^{[2
,3
]}

Huang, Yi ^{[2
,3
]}

Chen, Yongsheng ^{[2
,3
]}

机构：

[1] Tianjin Med Univ, Sch Pharmaceut Sci, Tianjin 300070, Peoples R China

[2] Nankai Univ, Coll Chem, Inst Polymer Chem, Key Lab Funct Polymer Mat, Tianjin 300071, Peoples R China

[3] Nankai Univ, Ctr Nanoscale Sci & Technol, Tianjin 300071, Peoples R China

来源：

JOURNAL OF PHYSICAL CHEMISTRY C | 2008年 / 112卷 / 45期

关键词：

D O I：

10.1021/jp806751k

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A novel graphene oxide-doxorubicin hydrochloride nanohybrid (GO-DXR) was prepared via a simple noncovalent method, and the loading and release behaviors of DXR on GO were investigated. An efficient loading of DXR on GO as high as 2.35 mg/mg was obtained at the initial DXR concentration of 0.47 mg/mL. The loading and release of DXR on GO showed strong pH dependence, which may be due to the hydrogenbonding interaction between GO and DXR. The fluorescent spectrum and electrochemical results indicate that strong pi-pi stacking interaction exists between them.

引用

页码：17554 / 17558

页数：5

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