Antigenic and immunogenic properties of totally synthetic peptide-based anti-fertility vaccines

被引：48

作者：

Ghosh, S ^{[1
]}

Jackson, DC ^{[1
]}

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Cooperat Res Ctr Vaccine Technol, Parkville, Vic 3052, Australia

来源：

INTERNATIONAL IMMUNOLOGY | 1999年 / 11卷 / 07期

关键词：

immunocastration; luteinizing hormone releasing hormone; synthetic vaccine;

D O I：

10.1093/intimm/11.7.1103

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study we describe the results of experiments in which a variety of totally synthetic luteinizing hormone releasing hormone (LHRH) vaccines were assembled and examined for their abilities to elicit antibody responses and induce sterility in mice. It is shown that totally synthetic vaccines consisting of a 15 residue-defined T cell epitope and the 10 residue LHRH epitope not only induced high titers of antibody but also induced sterility. This effect did not appear to correlate with antibody titer, antibody isotype or comparative antibody affinity, but may be related to the length of time for which antibodies are present to exert their influence.

引用

页码：1103 / 1110

页数：8

共 36 条

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