Traditional Chinese Medicine in Cancer Care: A Review of Controlled Clinical Studies Published in Chinese

被引：189

作者：

Li, Xun ^{[1
,2
]}

Yang, Guoyan ^{[1
]}

Li, Xinxue ^{[1
]}

Zhang, Yan ^{[3
]}

Yang, Jingli ^{[4
]}

Chang, Jiu ^{[3
]}

Sun, Xiaoxuan ^{[3
]}

Zhou, Xiaoyun ^{[5
]}

Guo, Yu ^{[5
]}

Xu, Yue ^{[6
]}

Liu, Jianping ^{[1
]}

Bensoussan, Alan ^{[2
]}

机构：

[1] Beijing Univ Chinese Med, Ctr Evidence Based Chinese Med, Beijing, Peoples R China

[2] Univ Western Sydney, Ctr Complementary Med Res CompleMED, Sydney, NSW, Australia

[3] Beijing Univ Chinese Med, Sch Preclin Med, Beijing, Peoples R China

[4] Beijing Univ Chinese Med, Sch Management, Beijing, Peoples R China

[5] Beijing Univ Chinese Med, Sch Acupuncture & Moxibust, Beijing, Peoples R China

[6] Beijing Univ Chinese Med, Sch Humanities, Beijing, Peoples R China

来源：

PLOS ONE | 2013年 / 8卷 / 04期

关键词：

D O I：

10.1371/journal.pone.0060338

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Background: Traditional Chinese medicine (TCM) has been widely applied for cancer care in China. There have been a large number of controlled clinical studies published in Chinese literature, yet no systematic searching and analysis has been done. This study summarizes the current evidence of controlled clinical studies of TCM for cancer. Methods: We searched all the controlled clinical studies of TCM therapies for all kinds of cancers published in Chinese in four main Chinese electronic databases from their inception to November 2011. We bibliometrically analyzed the included studies and assessed the reporting quality. Results: A total of 2964 reports (involving 253,434 cancer patients) including 2385 randomized controlled trials and 579 non-randomized controlled studies were included. The top seven cancer types treated were lung cancer, liver cancer, stomach cancer, breast cancer, esophagus cancer, colorectal cancer and nasopharyngeal cancer by both study numbers and case numbers. The majority of studies (72%) applied TCM therapy combined with conventional treatment, whilst fewer (28%) applied only TCM therapy in the experimental groups. Herbal medicine was the most frequently applied TCM therapy (2677 studies, 90.32%). The most frequently reported outcome was clinical symptom improvement (1667 studies, 56.24%) followed by biomarker indices (1270 studies, 42.85%), quality of life (1129 studies, 38.09%), chemo/radiotherapy induced side effects (1094 studies, 36.91%), tumor size (869 studies, 29.32%) and safety (547 studies, 18.45%). Completeness and adequacy of reporting appeared to improve with time. Conclusions: Data from controlled clinical studies of TCM therapies in cancer treatment is substantial, and different therapies are applied either as monotherapy or in combination with conventional medicine. Reporting of controlled clinical studies should be improved based on the CONSORT and TREND Statements in future. Further studies should address the most frequently used TCM therapy for common cancers and outcome measures should address survival, relapse/metastasis and quality of life.

引用

页数：11

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