Lipid trafficking to the outer membrane of Gram-negative bacteria

被引:84
作者
Doerrler, WT [1 ]
机构
[1] Louisiana State Univ, Dept Biol Sci, Baton Rouge, LA 70803 USA
关键词
D O I
10.1111/j.1365-2958.2006.05130.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The envelope of Gram-negative bacteria is composed of two distinct lipid membranes: an inner membrane and outer membrane. The outer membrane is an asymmetric bilayer with an inner leaflet of phospholipids and an outer leaflet of lipopolysaccharide. Most of the steps of lipid synthesis occur within the cytoplasmic compartment of the cell. Lipids must then be transported across the inner membrane and delivered to the outer membrane. These topological features combined with the ability to apply the tools of biochemistry and genetics make the Gram-negative envelope a fascinating model for the study of lipid trafficking. In addition, as lipopolysaccharide is essential for growth of most strains and is a potent inducer of the mammalian innate immune response via activation of Toll-like receptors, Gram-negative lipid transport is also a promising target for the development of novel antibacterial and anti-inflammatory compounds. This review focuses on recent developments in our understanding of lipid transport across the inner membrane and to the outer membrane of Gram-negative bacteria.
引用
收藏
页码:542 / 552
页数:11
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共 73 条
[1]   Biochemical, cellular, and pharmacological aspects of the multidrug transporter [J].
Ambudkar, SV ;
Dey, S ;
Hrycyna, CA ;
Ramachandra, M ;
Pastan, I ;
Gottesman, MM .
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1999, 39 :361-398
[2]   CLONING OF ORGANIC-SOLVENT TOLERANCE GENE OSTA THAT DETERMINES N-HEXANE TOLERANCE LEVEL IN ESCHERICHIA-COLI [J].
AONO, R ;
NEGISHI, T ;
NAKAJIMA, H .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1994, 60 (12) :4624-4626
[3]   AREAS OF ADHESION BETWEEN WALL AND MEMBRANE OF ESCHERICHIA COLI [J].
BAYER, ME .
JOURNAL OF GENERAL MICROBIOLOGY, 1968, 53 :395-&
[4]   ZONES OF MEMBRANE ADHESION IN THE CRYOFIXED ENVELOPE OF ESCHERICHIA-COLI [J].
BAYER, ME .
JOURNAL OF STRUCTURAL BIOLOGY, 1991, 107 (03) :268-280
[5]   The Protein Data Bank [J].
Berman, HM ;
Westbrook, J ;
Feng, Z ;
Gilliland, G ;
Bhat, TN ;
Weissig, H ;
Shindyalov, IN ;
Bourne, PE .
NUCLEIC ACIDS RESEARCH, 2000, 28 (01) :235-242
[6]   Inferences, questions and possibilities in toll-like receptor signalling [J].
Beutler, B .
NATURE, 2004, 430 (6996) :257-263
[7]   The lipid A palmitoyltransferase PagP: molecular mechanisms and role in bacterial pathogenesis [J].
Bishop, RE .
MOLECULAR MICROBIOLOGY, 2005, 57 (04) :900-912
[8]   Identification of an outer membrane protein required for the transport of lipopolysaccharide to the bacterial cell surface [J].
Bos, MP ;
Tefsen, B ;
Geurtsen, J ;
Tommassen, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (25) :9417-9422
[9]   Imp/OstA is required for cell envelope biogenesis in Escherichia coli [J].
Braun, M ;
Silhavy, TJ .
MOLECULAR MICROBIOLOGY, 2002, 45 (05) :1289-1302
[10]   A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid a with 4-amino-4-deoxy-L-arabinose -: Identification and function of UDP-4-deoxy-4-formamido-L-arabinose [J].
Breazeale, SD ;
Ribeiro, AA ;
McClerren, AL ;
Raetz, RH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (14) :14154-14167