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Danger - misfolding proteins
被引:117
作者
:
Ellis, RJ
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Warwick, Dept Biol Sci, Coventry CV4 7AL, W Midlands, England
Univ Warwick, Dept Biol Sci, Coventry CV4 7AL, W Midlands, England
Ellis, RJ
[
1
]
Pinheiro, TJT
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Warwick, Dept Biol Sci, Coventry CV4 7AL, W Midlands, England
Univ Warwick, Dept Biol Sci, Coventry CV4 7AL, W Midlands, England
Pinheiro, TJT
[
1
]
机构
:
[1]
Univ Warwick, Dept Biol Sci, Coventry CV4 7AL, W Midlands, England
来源
:
NATURE
|
2002年
/ 416卷
/ 6880期
关键词
:
D O I
:
10.1038/416483a
中图分类号
:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号
:
07 ;
0710 ;
09 ;
摘要
:
Protein folding is vital to living organisms because it adds functional flesh to the bare bones of genes. But errors in this process generate misfolded structures that can be lethal.
引用
收藏
页码:483 / 484
页数:2
相关论文
共 10 条
[1]
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
[J].
Bucciantini, M
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Bucciantini, M
;
Giannoni, E
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Giannoni, E
;
Chiti, F
论文数:
0
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0
h-index:
0
机构:
Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Chiti, F
;
Baroni, F
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Baroni, F
;
Formigli, L
论文数:
0
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0
h-index:
0
机构:
Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Formigli, L
;
Zurdo, JS
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0
引用数:
0
h-index:
0
机构:
Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Zurdo, JS
;
Taddei, N
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Taddei, N
;
Ramponi, G
论文数:
0
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h-index:
0
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Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Ramponi, G
;
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0
引用数:
0
h-index:
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Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Dobson, CM
;
Stefani, M
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Stefani, M
.
NATURE,
2002,
416
(6880)
:507
-511
[2]
Role of Escherichia coli curli operons in directing amyloid fiber formation
[J].
Chapman, MR
论文数:
0
引用数:
0
h-index:
0
机构:
Washington Univ, Sch Med, Dept Mol Microbiol & Microbial Pathogenesis, St Louis, MO 63110 USA
Chapman, MR
;
Robinson, LS
论文数:
0
引用数:
0
h-index:
0
机构:
Washington Univ, Sch Med, Dept Mol Microbiol & Microbial Pathogenesis, St Louis, MO 63110 USA
Robinson, LS
;
Pinkner, JS
论文数:
0
引用数:
0
h-index:
0
机构:
Washington Univ, Sch Med, Dept Mol Microbiol & Microbial Pathogenesis, St Louis, MO 63110 USA
Pinkner, JS
;
Roth, R
论文数:
0
引用数:
0
h-index:
0
机构:
Washington Univ, Sch Med, Dept Mol Microbiol & Microbial Pathogenesis, St Louis, MO 63110 USA
Roth, R
;
Heuser, J
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0
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0
h-index:
0
机构:
Washington Univ, Sch Med, Dept Mol Microbiol & Microbial Pathogenesis, St Louis, MO 63110 USA
Heuser, J
;
Hammar, M
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0
引用数:
0
h-index:
0
机构:
Washington Univ, Sch Med, Dept Mol Microbiol & Microbial Pathogenesis, St Louis, MO 63110 USA
Hammar, M
;
Normark, S
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0
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0
h-index:
0
机构:
Washington Univ, Sch Med, Dept Mol Microbiol & Microbial Pathogenesis, St Louis, MO 63110 USA
Normark, S
;
Hultgren, SJ
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0
引用数:
0
h-index:
0
机构:
Washington Univ, Sch Med, Dept Mol Microbiol & Microbial Pathogenesis, St Louis, MO 63110 USA
Hultgren, SJ
.
SCIENCE,
2002,
295
(5556)
:851
-855
[3]
Protein misfolding, evolution and disease
[J].
Dobson, CM
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Oxford, New Chem Lab, Oxford Ctr Mol Sci, Oxford OX1 3QT, England
Univ Oxford, New Chem Lab, Oxford Ctr Mol Sci, Oxford OX1 3QT, England
Dobson, CM
.
TRENDS IN BIOCHEMICAL SCIENCES,
1999,
24
(09)
:329
-332
[4]
Protein misfolding and disease - Preface
[J].
Dobson, CM
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Oxford, Oxford Ctr Mol Sci, New Chem Lab, Oxford OX1 3QT, England
Dobson, CM
;
Ellis, RJ
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Oxford, Oxford Ctr Mol Sci, New Chem Lab, Oxford OX1 3QT, England
Ellis, RJ
;
Fersht, AR
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Oxford, Oxford Ctr Mol Sci, New Chem Lab, Oxford OX1 3QT, England
Fersht, AR
.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES,
2001,
356
(1406)
:129
-131
[5]
Macromolecular crowding: obvious but underappreciated
[J].
Ellis, RJ
论文数:
0
引用数:
0
h-index:
0
机构:
Dept of Biological Sciences, University of Warwick, Coventry
Ellis, RJ
.
TRENDS IN BIOCHEMICAL SCIENCES,
2001,
26
(10)
:597
-604
[6]
Amyloid fibrils from muscle myoglobin -: Even an ordinary globular protein can assume a rogue guise if conditions are right.
[J].
Fändrich, M
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Oxford, New Chem Lab, Oxford Ctr Mol Sci, Oxford OX1 3QT, England
Univ Oxford, New Chem Lab, Oxford Ctr Mol Sci, Oxford OX1 3QT, England
Fändrich, M
;
Fletcher, MA
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Oxford, New Chem Lab, Oxford Ctr Mol Sci, Oxford OX1 3QT, England
Univ Oxford, New Chem Lab, Oxford Ctr Mol Sci, Oxford OX1 3QT, England
Fletcher, MA
;
Dobson, CM
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Oxford, New Chem Lab, Oxford Ctr Mol Sci, Oxford OX1 3QT, England
Univ Oxford, New Chem Lab, Oxford Ctr Mol Sci, Oxford OX1 3QT, England
Dobson, CM
.
NATURE,
2001,
410
(6825)
:165
-166
[7]
Kim JH, 2001, J NEUROSCI, V21, P1327
[8]
Implications of macromolecular crowding for protein assembly
[J].
Minton, AP
论文数:
0
引用数:
0
h-index:
0
机构:
NIDDKD, Lab Biochem & Genet, Sect Phys Biochem, NIH, Bethesda, MD 20892 USA
NIDDKD, Lab Biochem & Genet, Sect Phys Biochem, NIH, Bethesda, MD 20892 USA
Minton, AP
.
CURRENT OPINION IN STRUCTURAL BIOLOGY,
2000,
10
(01)
:34
-39
[9]
Alzheimer's disease: Genes, proteins, and therapy
[J].
Selkoe, DJ
论文数:
0
引用数:
0
h-index:
0
机构:
Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA
Selkoe, DJ
.
PHYSIOLOGICAL REVIEWS,
2001,
81
(02)
:741
-766
[10]
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
[J].
Walsh, DM
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Walsh, DM
;
Klyubin, I
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Klyubin, I
;
Fadeeva, JV
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Fadeeva, JV
;
Cullen, WK
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Cullen, WK
;
Anwyl, R
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Anwyl, R
;
Wolfe, MS
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Wolfe, MS
;
论文数:
引用数:
h-index:
机构:
Rowan, MJ
;
Selkoe, DJ
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Selkoe, DJ
.
NATURE,
2002,
416
(6880)
:535
-539
←
1
→
共 10 条
[1]
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
[J].
Bucciantini, M
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Bucciantini, M
;
Giannoni, E
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Giannoni, E
;
Chiti, F
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Chiti, F
;
Baroni, F
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Baroni, F
;
Formigli, L
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Formigli, L
;
Zurdo, JS
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Zurdo, JS
;
Taddei, N
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Taddei, N
;
Ramponi, G
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Ramponi, G
;
Dobson, CM
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Dobson, CM
;
Stefani, M
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Stefani, M
.
NATURE,
2002,
416
(6880)
:507
-511
[2]
Role of Escherichia coli curli operons in directing amyloid fiber formation
[J].
Chapman, MR
论文数:
0
引用数:
0
h-index:
0
机构:
Washington Univ, Sch Med, Dept Mol Microbiol & Microbial Pathogenesis, St Louis, MO 63110 USA
Chapman, MR
;
Robinson, LS
论文数:
0
引用数:
0
h-index:
0
机构:
Washington Univ, Sch Med, Dept Mol Microbiol & Microbial Pathogenesis, St Louis, MO 63110 USA
Robinson, LS
;
Pinkner, JS
论文数:
0
引用数:
0
h-index:
0
机构:
Washington Univ, Sch Med, Dept Mol Microbiol & Microbial Pathogenesis, St Louis, MO 63110 USA
Pinkner, JS
;
Roth, R
论文数:
0
引用数:
0
h-index:
0
机构:
Washington Univ, Sch Med, Dept Mol Microbiol & Microbial Pathogenesis, St Louis, MO 63110 USA
Roth, R
;
Heuser, J
论文数:
0
引用数:
0
h-index:
0
机构:
Washington Univ, Sch Med, Dept Mol Microbiol & Microbial Pathogenesis, St Louis, MO 63110 USA
Heuser, J
;
Hammar, M
论文数:
0
引用数:
0
h-index:
0
机构:
Washington Univ, Sch Med, Dept Mol Microbiol & Microbial Pathogenesis, St Louis, MO 63110 USA
Hammar, M
;
Normark, S
论文数:
0
引用数:
0
h-index:
0
机构:
Washington Univ, Sch Med, Dept Mol Microbiol & Microbial Pathogenesis, St Louis, MO 63110 USA
Normark, S
;
Hultgren, SJ
论文数:
0
引用数:
0
h-index:
0
机构:
Washington Univ, Sch Med, Dept Mol Microbiol & Microbial Pathogenesis, St Louis, MO 63110 USA
Hultgren, SJ
.
SCIENCE,
2002,
295
(5556)
:851
-855
[3]
Protein misfolding, evolution and disease
[J].
Dobson, CM
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Oxford, New Chem Lab, Oxford Ctr Mol Sci, Oxford OX1 3QT, England
Univ Oxford, New Chem Lab, Oxford Ctr Mol Sci, Oxford OX1 3QT, England
Dobson, CM
.
TRENDS IN BIOCHEMICAL SCIENCES,
1999,
24
(09)
:329
-332
[4]
Protein misfolding and disease - Preface
[J].
Dobson, CM
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Oxford, Oxford Ctr Mol Sci, New Chem Lab, Oxford OX1 3QT, England
Dobson, CM
;
Ellis, RJ
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Oxford, Oxford Ctr Mol Sci, New Chem Lab, Oxford OX1 3QT, England
Ellis, RJ
;
Fersht, AR
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Oxford, Oxford Ctr Mol Sci, New Chem Lab, Oxford OX1 3QT, England
Fersht, AR
.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES,
2001,
356
(1406)
:129
-131
[5]
Macromolecular crowding: obvious but underappreciated
[J].
Ellis, RJ
论文数:
0
引用数:
0
h-index:
0
机构:
Dept of Biological Sciences, University of Warwick, Coventry
Ellis, RJ
.
TRENDS IN BIOCHEMICAL SCIENCES,
2001,
26
(10)
:597
-604
[6]
Amyloid fibrils from muscle myoglobin -: Even an ordinary globular protein can assume a rogue guise if conditions are right.
[J].
Fändrich, M
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Oxford, New Chem Lab, Oxford Ctr Mol Sci, Oxford OX1 3QT, England
Univ Oxford, New Chem Lab, Oxford Ctr Mol Sci, Oxford OX1 3QT, England
Fändrich, M
;
Fletcher, MA
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Oxford, New Chem Lab, Oxford Ctr Mol Sci, Oxford OX1 3QT, England
Univ Oxford, New Chem Lab, Oxford Ctr Mol Sci, Oxford OX1 3QT, England
Fletcher, MA
;
Dobson, CM
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Oxford, New Chem Lab, Oxford Ctr Mol Sci, Oxford OX1 3QT, England
Univ Oxford, New Chem Lab, Oxford Ctr Mol Sci, Oxford OX1 3QT, England
Dobson, CM
.
NATURE,
2001,
410
(6825)
:165
-166
[7]
Kim JH, 2001, J NEUROSCI, V21, P1327
[8]
Implications of macromolecular crowding for protein assembly
[J].
Minton, AP
论文数:
0
引用数:
0
h-index:
0
机构:
NIDDKD, Lab Biochem & Genet, Sect Phys Biochem, NIH, Bethesda, MD 20892 USA
NIDDKD, Lab Biochem & Genet, Sect Phys Biochem, NIH, Bethesda, MD 20892 USA
Minton, AP
.
CURRENT OPINION IN STRUCTURAL BIOLOGY,
2000,
10
(01)
:34
-39
[9]
Alzheimer's disease: Genes, proteins, and therapy
[J].
Selkoe, DJ
论文数:
0
引用数:
0
h-index:
0
机构:
Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA
Selkoe, DJ
.
PHYSIOLOGICAL REVIEWS,
2001,
81
(02)
:741
-766
[10]
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
[J].
Walsh, DM
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Walsh, DM
;
Klyubin, I
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Klyubin, I
;
Fadeeva, JV
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Fadeeva, JV
;
Cullen, WK
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Cullen, WK
;
Anwyl, R
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Anwyl, R
;
Wolfe, MS
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Wolfe, MS
;
论文数:
引用数:
h-index:
机构:
Rowan, MJ
;
Selkoe, DJ
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Selkoe, DJ
.
NATURE,
2002,
416
(6880)
:535
-539
←
1
→