Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys

被引：296

作者：

Chen, G

Qian, H

Starz, T

Sun, HT

Garcia, B

Wang, XM

Wise, Y

Liu, YQ

Xiang, Y

Copeman, L

Liu, WH

Jevnikar, A

Wall, W

Cooper, DKC

Murase, N

Dai, YF

Wang, WY

Xiong, YL

White, DJ

Zhong, R ^{[1
]}

机构：

[1] Univ Western Ontario, Dept Surg, London, ON N6A 5C1, Canada

[2] Univ Pittsburgh, Ctr Med, Thomas E Starzl Transplantat Inst, Pittsburgh, PA 15213 USA

[3] Univ Western Ontario, Dept Pathol, London, ON N6A 5A5, Canada

[4] Robarts Res Inst, Transplantat Grp, London, ON N6A 5C1, Canada

[5] Univ Western Ontario, Dept Med, London, ON N6A 5A5, Canada

[6] London Hlth Sci Ctr, Lawson Hlth Res Inst, London, ON N6A 5A5, Canada

[7] London Hlth Sci Ctr, Multi Organ Transplant Program, London, ON N6A 5A5, Canada

[8] Revivcor Inc, Blacksburg, VA 24060 USA

[9] Chinese Acad Sci, Kunming Inst Zool, Anim Toxicol Lab, Kunming, Peoples R China

[10] Univ Western Ontario, Dept Microbiol & Immunol, London, ON N6A 5C1, Canada

来源：

NATURE MEDICINE | 2005年 / 11卷 / 12期

关键词：

D O I：

10.1038/nm1330

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We transplanted kidneys from alpha 1,3-galactosyltransferase knockout (GalT-KO) pigs into six baboons using two different immunosuppressive regimens, but most of the baboons died from severe acute humoral xenograft rejection. Circulating induced antibodies to non-Gal antigens were markedly elevated at rejection, which mediated strong complement-dependent cytotoxicity against GaIT-KO porcine target cells. These data suggest that antibodies to non-Gal antigens will present an additional barrier to transplantation of organs from GaIT-KO pigs to humans.

引用

页码：1295 / 1298

页数：4

共 15 条

[1] Three-month survival of HDAFF transgenic pig hearts transplanted into primates [J].