Vitamin D Deficiency An Important, Common, and Easily Treatable Cardiovascular Risk Factor?

被引:569
作者
Lee, John H. [1 ,2 ]
O'Keefe, James H. [1 ,2 ]
Bell, David [3 ]
Hensrud, Donald D. [4 ]
Holick, Michael F. [5 ]
机构
[1] St Lukes Hosp, Mid Amer Heart Inst, Kansas City, MO 64111 USA
[2] Univ Missouri, Kansas City, MO 64110 USA
[3] Southside Endocrinol, Birmingham, AL USA
[4] Mayo Clin, Rochester, MN USA
[5] Boston Univ, Med Ctr, Boston, MA USA
关键词
vitamin D; 25-hydroxyvitamin D; calcium; coronary disease prevention; hypertension; diabetes;
D O I
10.1016/j.jacc.2008.08.050
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Vitamin D deficiency is a highly prevalent condition, present in approximately 30% to 50% of the general population. A growing body of data suggests that low 25-hydroxyvitamin D levels may adversely affect cardiovascular health. Vitamin D deficiency activates the renin-angiotensin-aldosterone system and can predispose to hypertension and left ventricular hypertrophy. Additionally, vitamin D deficiency causes an increase in parathyroid hormone, which increases insulin resistance and is associated with diabetes, hypertension, inflammation, and increased cardiovascular risk. Epidemiologic studies have associated low 25-hydroxyvitamin D levels with coronary risk factors and adverse cardiovascular outcomes. Vitamin D supplementation is simple, safe, and inexpensive. Large randomized controlled trials are needed to firmly establish the relevance of vitamin D status to cardiovascular health. In the meanwhile, monitoring serum 25-hydroxyvitamin D levels and correction of vitamin D deficiency is indicated for optimization of musculoskeletal and general health. (J Am Coll Cardiol 2008;52:1949-56) (C) 2008 by the American College of Cardiology Foundation
引用
收藏
页码:1949 / 1956
页数:8
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